A2201

Amyloid β-Protein Fragment 35-25

≥95% (HPLC)

• Wzór empiryczny (zapis Hilla): C₄₅H₈₁N₁₃O₁₄S
• Numer CAS: 147740-73-6
• Masa cząsteczkowa: 1060.27
• Numer MDL: MFCD00214225
• Kod UNSPSC: 51111800
• Identyfikator substancji w PubChem: 24890634
• NACRES: NA.32

Właściwości

• Poziom jakości: 200
• Próba: ≥95% (HPLC)
• Formularz: powder
• numer dostępu UniProt: P05067
• temp. przechowywania: −20°C
• ciąg SMILES: CCC(C)C(NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(N)CCSC)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CO)C(=O)NCC(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(57-34(62)20-50-40(67)29(17-23(3)4)54-39(66)27(47)14-16-73-8)45(72)58-37(25(6)10-2)44(71)52-26(7)38(65)49-19-33(61)53-28(13-11-12-15-46)42(69)55-30(18-32(48)60)43(70)56-31(22-59)41(68)51-21-35(63)64/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,67)(H,51,68)(H,52,71)(H,53,61)(H,54,66)(H,55,69)(H,56,70)(H,57,62)(H,58,72)(H,63,64)
• Klucz InChI: IDGOADDOQWKZOX-UHFFFAOYSA-N
• informacje o genach: human ... APP(351)

Opis

Amino Acid Sequence

Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly

Opis ogólny

Amyloid β precursor protein (APP) is a type-1 transmembrane protein.[1] APP is expressed widely and mainly found in the synapses and neurons.[2] The APP gene is mapped to human chromosome 21q21.3.[3]

Zastosowanie

Amyloid β-Protein Fragment 35-25 has been used as a control peptide for Aβ-induced apoptosis to study the role of hepcidin overexpression in astrocytes against amyloid-β induced brain damage in mice.[4]

Działania biochem./fizjol.

Proteolytic processing of amyloid β precursor protein (APP) forms the β amyloid protein (Aβ) as part of the brain amyloid plaques[1] which are the key biomarkers in Alzheimer′s disease. APP is known to be associated with neurogenesis, synapse formation, axonal transport, neuronal migration and neurite outgrowth. It is also related to mitochondria-associated endoplasmic reticulum membranes (MAMs) activity, antimicrobial protection, cholesterol, and iron homeostasis.[2][1] Amyloid β-Protein Fragment 35-25 is an inactive control.

Inne uwagi

The N—C inverted sequence of fragment 25-35

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)