83580

Reserpine

≥99.0% (HPLC), serotonin uptake inhibitor, solid

• Synonim(y): (3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
• Wzór empiryczny (zapis Hilla): C₃₃H₄₀N₂O₉
• Numer CAS: 50-55-5
• Masa cząsteczkowa: 608.68
• NACRES: NA.77
• PubChem Substance ID: 329769078
• UNSPSC Code: 12352200
• EC Number: 200-047-9
• MDL number: MFCD00005091
• Beilstein/REAXYS Number: 102014
• Assay: ≥99.0% (HPLC)
• Form: solid

Właściwości

• Nazwa produktu: Reserpine, crystallized, ≥99.0% (HPLC)
• assay: ≥99.0% (HPLC)
• form: solid
• optical activity: [α]20/D −123±3°, c = 1% in chloroform
• quality: crystallized
• mp: ~265 °C (dec.)
• SMILES string: CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
• InChI: 1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
• InChI key: QEVHRUUCFGRFIF-MDEJGZGSSA-N
• Gene Information: human ... SLC18A2(6571)

Opis

General description

Reserpine is an indole alkaloid that irreversibly binds vesicular monoamine transporters VMAT1 and VMAT2. It is a sympatholytic drug useful in treating systemic hypertension.

Application

Reserpine has been used as a test chemical in performance studies.

Biochem/physiol Actions

Reserpine is used to treat hypertensive pregnancy difficulties. This drug is also considered as antipsychotic and antihypertensive, to regulate high blood pressure.

Inhibits vesicular uptake of catecholamines and serotonin.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302,H336,H351,H360D
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
• target_organs: Central nervous system
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves