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Merck

74023

Supelco

trans-2-Dodecenoyl-L-carnitine

analytical standard

Synonim(y):

(2R)-3-Carboxy-N,N,N-trimethyl-2-[[(2E)-1-oxo-2-dodecen-1-yl]oxy]-1-propanaminium inner salt, C12:1-Carnitine

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About This Item

Wzór empiryczny (zapis Hilla):
C19H35NO4
Numer CAS:
Masa cząsteczkowa:
341.49
Kod UNSPSC:
12352200
NACRES:
NB.21

klasa czystości

analytical standard

Poziom jakości

Próba

≥93.0% (HPLC)

aktywność optyczna

[α]/D -15±2°, c = 0.1 in methanol

okres trwałości

limited shelf life, expiry date on the label

Zastosowanie

clinical testing

format

neat

temp. przechowywania

−20°C

ciąg SMILES

[O-]C(C([H])([H])[C@](OC(/C([H])=C([H])/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)([H])C([H])([H])[N+](C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])=O

Opis ogólny

trans-2-Dodecenoyl-L-carnitine belongs to the class of medium-chain acylcarnitines. Acyl-L-carnitines are mostly produced from L-carnitine, which plays an important role in fatty acid metabolic pathways. It acts as a carrier of long-chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.
trans-2-Dodecenoyl-L-carnitine, belongs to the class of acylcarnitines. It serves as a specific diagnostic metabolite biomarker, which increases in very-long-chain acyl CoA dehydrogenase (VLCAD) deficiency, determined in biological samples.

Zastosowanie

trans-2-Dodecenoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological fluids of horses with atypical myopathy using gas chromatography coupled to mass spectrometry. It may also be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS).
trans-2-Dodecenoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological samples of horses with atypical myopathy using gas chromatography-mass spectrometry (GC−MS). It may also be used as an analytical standard to quantify the analyte in biological samples of patients with continuous ambulatory peritoneal dialysis (CAPD) or automated peritoneal dialysis (APD) using high-performance liquid chromatography/tandem quadrupole mass spectrometry (HPLC-TQMS).

Polecane produkty

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


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Certyfikaty analizy (CoA)

Lot/Batch Number

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Acylcarnitines-old actors auditioning for new roles in metabolic physiology
McCoin SC, et al.
Nature reviews. Endocrinology, 11(10), 617-617 (2015)
Current methods for determination of L-carnitine and acylcarnitine
Moder M, et al.
Monatshefte fur Chemie / Chemical Monthly, 136(8), 1279-1291 (2005)
Acylcarnitine esters profiling of serum and follicular fluid in patients undergoing in vitro fertilization
Varnagy A, et al.
Reproductive Biology and Endocrinology, 11(1), 67-67 (2013)
Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy
Westermann MC, et al.
Neuromuscular Disorders, 18(5), 355-364 (2008)
L-Carnitine status in end-stage renal disease patients on automated peritoneal dialysis
Liberato DL , et al.
Journal of Nephrology, 27(6), 699-706 (2014)

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