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Supelco

Methimazole

VETRANAL®, analytical standard

Synonim(y):

1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole

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About This Item

Wzór empiryczny (zapis Hilla):
C4H6N2S
Numer CAS:
60-56-0
Masa cząsteczkowa:
114.17
Beilstein:
108646
Numer WE:
200-482-4
Numer MDL:
MFCD00179321
Kod UNSPSC:
41116107
Identyfikator substancji w PubChem:
329757178
NACRES:
NA.24

klasa czystości

analytical standard

Poziom jakości

200

linia produktu

VETRANAL®

okres trwałości

limited shelf life, expiry date on the label

metody

HPLC: suitable
gas chromatography (GC): suitable

mp

144-147 °C (lit.)

Zastosowanie

cleaning products
clinical
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

format

neat

ciąg SMILES

CN1C=CNC1=S

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

Klucz InChI

PMRYVIKBURPHAH-UHFFFAOYSA-N

informacje o genach

human ... TPO(7173)

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Opis ogólny

Methimazole is a thyreostatic compound, and an antihormone, which is widely used in medicine for the treatment of hyperthyroidism.

Zastosowanie

Methimazole may be used as a reference standard for the determination of the analyte in fish homogenates using mixed mode solid-phase extraction technique with reversed-phase high-performance liquid chromatography method with ultraviolet detection (MMSPE-RP-HPLC-UV).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informacje prawne

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
This page may contain text that has been machine translated.

Piktogramy

Health hazardExclamation mark
GHS08,GHS07

Hasło ostrzegawcze

Warning

Zwroty wskazujące rodzaj zagrożenia

H302,H317,H319,H361fd

Klasyfikacja zagrożeń

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Sens. 1

Kod klasy składowania

11 - Combustible Solids

Klasa zagrożenia wodnego (WGK)

WGK 3

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Środki ochrony indywidualnej

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certyfikaty analizy (CoA)

Lot/Batch Number
BCCG2061
BCBZ9652
BCBS5704V
SZBE043XV
SZBB052XV

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Mal-Soon Shin et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 31(3), 214-223 (2013-01-19)
Thyroid hormones play a crucial role in new neuron production and maturation during brain development. Physical exercise is known to promote cell survival and functional recovery after brain injuries. In the present study, we investigated the effects of treadmill exercise
MMSPE-RP-HPLC method for the simultaneous determination of methimazole and selected metabolites in fish homogenates.
Hollosi L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(4), 921-924 (2004)
Stijn L J Van Herck et al.
The Journal of endocrinology, 218(1), 105-115 (2013-04-24)
Methimazole (MMI) is an anti-thyroid drug used in the treatment of chronic hyperthyroidism. There is, however, some debate about its use during pregnancy as MMI is known to cross the mammalian placenta and reach the developing foetus. A similar problem
F S Boretti et al.
Journal of veterinary internal medicine, 27(2), 377-381 (2013-02-13)
Transdermal methimazole is an acceptable alternative to oral treatment for hyperthyroid cats. There are, however, no studies evaluating the duration of T4 suppression after transdermal methimazole application. Such information would be valuable for therapeutic monitoring. To assess variation in serum
Fernando Bolaños et al.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 54(4), 307-310 (2002-11-06)
Long-term thionamide treatment is considered one of the main resources for Graves' hyperthyroidism. Although a 54.2% remission rate in patients so treated in Mexico was previously reported, most articles have shown a wide variation over time. In the present article
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