P3755

6-Propyl-2-thiouracil

≥99% (HPLC), powder

• Synonim(y): 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone, 4-Hydroxy-2-mercapto-6-propylpyrimidine
• Wzór empiryczny (zapis Hilla): C₇H₁₀N₂OS
• Numer CAS: 51-52-5
• Masa cząsteczkowa: 170.23
• NACRES: NA.51
• PubChem Substance ID: 24898446
• UNSPSC Code: 41106305
• EC Number: 200-103-2
• MDL number: MFCD00006041
• Beilstein/REAXYS Number: 130039
• Assay: ≥99% (HPLC)
• Form: powder
• Solubility: 10% NH₃: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

Właściwości

• Nazwa produktu: 6-Propyl-2-thiouracil, enzyme inhibitor
• Quality Segment: 200
• assay: ≥99% (HPLC)
• form: powder
• mp: 218-220 °C (lit.)
• solubility: 10% NH₃: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• SMILES string: CCCC1=CC(=O)NC(=S)N1
• InChI: 1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
• InChI key: KNAHARQHSZJURB-UHFFFAOYSA-N
• Gene Information: human ... DIO1(1733), TPO(7173)

Opis

General description

6-Propyl-2-thiouracil or 6-n-Propylthiouracil (PROP) is a compound with a bitter taste.[1]

Application

6-Propyl-2-thiouracil (PROP) has been used to impregnate on disk for PROP taster status studies for sensory characterization in a defined human sample group.[1][2] It has been used as a screening agent for testing the intensity of taste by labeled magnitude scale (LMS).

6-Propyl-2-thiouracil is a thyreostatic (thyroid hormone) agent that may be used as a reference material in thyreostatic drug separation and detection technologies such as capillary electrophoresis, high performance liquid chromatography (HPLC), or gas chromatography.

Biochem/physiol Actions

6-Propyl-2-thiouracil (6-PTU), a potential inhibitor of D1 iodothyronine deiodinase, is involved in the deiodination of iodothyronines. It is an uncompetitive inhibitor of iodothyronine substrates.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H351
• pcodes: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges