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MAB348A4

Sigma-Aldrich

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj.

clone 22C11, from mouse, ALEXA FLUOR™ 488

Synonim(y):

Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

100

białko sprzężone

ALEXA FLUOR™ 488

forma przeciwciała

purified immunoglobulin

rodzaj przeciwciała

primary antibodies

klon

22C11, monoclonal

reaktywność gatunkowa

rat, pig

reaktywność gatunkowa (przewidywana na podstawie homologii)

mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), porcine (based on 100% sequence homology), human (based on 100% sequence homology), canine (based on 100% sequence homology)

metody

immunocytochemistry: suitable
immunohistochemistry: suitable

izotyp

IgG1

numer dostępu NCBI

NP_000475

numer dostępu UniProt

P05067

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... APP(351)

Opis ogólny

Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged human and cases of Alzheimer′s Disease. The principle component of this extracellular amyloid is beta A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins is currently an active area of research.

Specyficzność

Unconjugated MAB348 recognizes N-terminal amino acids 66-81 on the pre-A4 molecule (Hilbich et al., 1993). 22C11 recognizes all three isoforms of APP: immature, ~110kDa; sAPP, ~120kDa; and mature, ~130kDa (Hoffmann et al., 2000). This antibody is known to cross react with APLP2 (Slunt, 1994).

Immunogen

Epitope: a.a. 66-81 of APP (N-terminus)

Zastosowanie

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Alexa488 Conj. is an antibody against Alzheimer Precursor Protein A4 for use in IHC, ICC.
Immunohistochmeistry Analysis: A 1:50 dilution from a representative lot detected Alzheimer Precursor Protein A4 in adult mouse brain tissue.

Jakość

Evaluated by Immunocytochemistry in mouse N1E-115 neuroblastoma cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in mouse N1E-115 neuroblastoma cells.

Opis wartości docelowych

Reacts with pre-A4. The unconjugated antibody (MAB348) recognizes all three isoforms of APP, immature ~110kDa, sAPP ~120kDa, and mature ~130kDa (Hoffmann et al., 2000).

Komentarz do analizy

Control
Mouse N1E-115 neuroblastoma cells

Informacje prawne

ALEXA FLUOR is a trademark of Life Technologies
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable

Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

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Nature communications, 12(1), 683-683 (2021-01-31)
Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune modulators. Neutrophils release histone-bound nuclear DNA and cytotoxic granules as extracellular traps (NET). Here we show
Celina Eckfeld et al.
The Journal of cell biology, 222(2) (2023-01-12)
The emerging cytokine tissue inhibitor of metalloproteinases-1 (TIMP-1) correlates with the progression of inflammatory diseases, including cancer. However, the effects of TIMP-1 on immune cell activation and underlying molecular mechanisms are largely unknown. Unbiased ligand-receptor-capture-screening revealed TIMP-1-interaction with Amyloid Precursor
Jung-Hyun Lee et al.
EBioMedicine, 77, 103903-103903 (2022-02-28)
Plasma extracellular vesicles (pEV) can harbor a diverse array of factors including active proteases and the amyloid-precursor-protein (APP) cleavage product Aβ, involved in plaque formation in Alzheimer`s diseases (AD). A potential role of such vesicles in AD pathology is unexplored.

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