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MAB2076Z

Sigma-Aldrich

Anti-Integrin β6 Antibody, clone CSβ6, azide free

clone CSbeta6, Chemicon®, from mouse

Synonim(y):

MAB2076

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About This Item

Kod UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

pochodzenie biologiczne

mouse

Poziom jakości

forma przeciwciała

purified antibody

rodzaj przeciwciała

primary antibodies

klon

CSbeta6, monoclonal

reaktywność gatunkowa

human, monkey, rat, rabbit

spodziewany brak reakcji z

mouse

producent / nazwa handlowa

Chemicon®

metody

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

izotyp

IgG1

numer dostępu NCBI

numer dostępu UniProt

Warunki transportu

wet ice

docelowa modyfikacja potranslacyjna

unmodified

informacje o genach

human ... ITGB6(3694)
mouse ... Itgb6(16420)
rat ... Itgb6(311061)
rhesus monkey ... Itgb6(700454)

Powiązane kategorie

Specyficzność

Monoclonal antibody MAB2076Z, raised by immunizing beta6 knockout mice with recombinant secreted human alphavbeta6, is useful for flow cytometry and immunoprecipitation in all species tested, including mouse. It also works well for immunohistochemistry of acetone-fixed tissues in several species, including rat, rabbit, monkey, and human. The antibody does not work well for immunohistochemistry of mouse tissue. This antibody does not recognize the aV subunit and does not react with alphaV integrins other than alphavbeta6. Because the antibody is not effective in western blot, it is unknown whether the epitope recognized by the antibody localizes to the alphavbeta6 heterodimer or to the beta6 subunit only.

Immunogen

beta 6 knockout mice have been immunized with recombinant secreted human alpaVbeta6.

Zastosowanie

Anti-Integrin β6 Antibody, clone CSβ6, azide free detects level of Integrin β6 & has been published & validated for use in FC, IP, IC, IH.
Immunohistochemistry (acetone fixation): Effective for Rabbit, rat, monkey, and human. Not effective for mouse tissue.

Immunocytochemistry: Effective for F6, HT-29, H441 cell lines (others not tested).

Flow cytometry: Effective for all species tested, including rabbit, rat, monkey, human, and mouse.

Immunoprecipitation

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins

Postać fizyczna

Format: Purified
Sterile-filtered liquid at 1 mg/mL in PBS, containing no preservatives.

Przechowywanie i stabilność

Maintain at 2-8°C.

Inne uwagi

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informacje prawne

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kod klasy składowania

12 - Non Combustible Liquids

Klasa zagrożenia wodnego (WGK)

WGK 2

Temperatura zapłonu (°F)

Not applicable

Temperatura zapłonu (°C)

Not applicable


Certyfikaty analizy (CoA)

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Odwiedź Bibliotekę dokumentów

A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density.
Gray, BP; McGuire, MJ; Brown, KC
Testing null
A continuous bovine kidney cell line constitutively expressing bovine ?v?6 integrin has increased susceptibility to foot-and-mouth disease virus.
LaRocco, M; Krug, PW; Kramer, E; Ahmed, Z; Pacheco, JM; Duque, H; Baxt, B; Rodriguez, LL
Journal of Clinical Microbiology null
Novel ITGB6 variants cause hypoplastic-hypomineralized amelogenesis imperfecta and taurodontism: characterization of tooth phenotype and review of literature.
Sriwattanapong, et al.
BDJ open, 9, 15-15 (2023)
Yahui Jiang et al.
Frontiers in oncology, 11, 690618-690618 (2021-10-09)
Implantation metastasis is the main means of dissemination in ovarian cancer. Our previous studies showed that SET and MYND domain-containing protein 3 (SMYD3) expression was higher in ovarian cancer spheroids than in monolayers. SMYD3 enhancement of spheroid invasion and adhesion
Dana L Nettles et al.
Journal of anatomy, 204(6), 515-520 (2004-06-17)
In this study, we investigated the profile of integrin expression in human and porcine intervertebral disc tissue. Differences in extracellular matrix composition between anulus fibrosus (AF) and nucleus pulposus (NP) regions of the disc, as well as differences in cellular

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