428020

Latrunculin B

from Latrunculia magnifica, ≥95% (HPLC), solid, actin polymerization inhibitor, Calbiochem^®

• Synonim(y): Latrunculin B, Latrunculia magnifica
• Wzór empiryczny (zapis Hilla): C₂₀H₂₉NO₅S
• Numer CAS: 76343-94-7
• Masa cząsteczkowa: 395.51
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00270879
• Assay: ≥95% (HPLC)
• Form: solid
• Storage condition: OK to freeze

Właściwości

• Nazwa produktu: Latrunculin B, Latrunculia magnifica, Latrunculin B, CAS 76343-94-7, is a unique marine toxin that inhibits actin polymerization and disrupts microfilament organization. It is 10 to 100-fold more potent than cytochalasins.
• Quality Segment: 100
• description: Merck USA index - 14, 5378
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white to yellow
• solubility: DMSO: 25 mg/mL, ethanol: 25 mg/mL, methanol: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: S1C[C@H](NC1=O)[C@@]2(O[C@H]3C[C@@H](OC(=O)\C=C(/CC\C=C/[C@H](CC3)C)\C)C2)O
• InChI: 1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
• InChI key: NSHPHXHGRHSMIK-JRIKCGFMSA-N

Opis

General description

A structurally unique marine toxin. Inhibits actin polymerization in vitro and disrupts microfilament organization as well as microfilament-mediated processes. 10 to 100-fold more potent than cytochalasins.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Actin polymerization

Product does not compete with ATP.

Reversible: no

Other Notes

Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.
de Oliveira, C.A., and Mantovani, B. 1988. Life Sci.43, 1825.
Coue, M., et al. 1987. FEBS Lett.213, 316.
Spector, I., et al. 1983. Science219, 493.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable