344931-M

Furin Inhibitor II

The Furin Inhibitor II controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonim(y): Heksa-D-arginina, H-(D)RRRRRR-NH₂
• Wzór empiryczny (zapis Hilla): C₃₆H₇₅N₂₅O₆
• Masa cząsteczkowa: 954.14
• Kod UNSPSC: 12352200

Właściwości

• Poziom jakości: 100
• Próba: ≥95% (HPLC)
• Formularz: solid
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; desiccated (hygroscopic)
• kolor: white
• rozpuszczalność: water: 1 mg/mL; DMSO: soluble
• temp. przechowywania: −20°C

Opis

Opis ogólny

A polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.

A polyarginine that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.

Działania biochem./fizjol.

Primary Target
furin

Target K_i: 106 nM against Furin

Ostrzeżenie

Toxicity: Standard Handling (A)

Sekwencja

H-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂

Postać fizyczna

Supplied as a trifluoroacetate salt.

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Inne uwagi

Cameron, A., et al. 2000. J. Biol. Chem.275, 36741.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable