700078P

7α,25-dihydroxycholesterol-d6

Avanti Research^™ - A Croda Brand

• Synonim(y): 26,26,26,27,27,27-hexadeutero-7α,25-dihydroxycholesterol ; 111117
• Wzór empiryczny (zapis Hilla): C₂₇H₄₀D₆O₃
• Numer CAS: 2260669-11-0
• Masa cząsteczkowa: 424.69
• Kod UNSPSC: 41141804
• NACRES: NA.25

Właściwości

• opis: 7α,25-dihydroxycholesterol-d6
• Próba: >99% (TLC)
• Formularz: powder
• opakowanie: pkg of 1 × 1 mg (700078P-1mg)
• producent / nazwa handlowa: Avanti Research^™ - A Croda Brand
• Warunki transportu: dry ice
• temp. przechowywania: −20°C
• ciąg SMILES: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]
• InChI: 1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1/i2D3,3D3
• Klucz InChI: BQMSKLCEWBSPPY-WWCTWMKLSA-N

Opis

Opis ogólny

7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1).[1] The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7).[2] 7α,25-dihydroxycholesterol-d6 is the deuterated form of 7α,25-dihydroxycholesterol.

Zastosowanie

7α,25-dihydroxycholesterol-d6 has be used as an internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC–ESI-MS/MS) analysis of human plasma.[3]

Działania biochem./fizjol.

7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property.[1] Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.[4]

Opakowanie

5 mL Amber Glass Screw Cap Vial (700078P-1mg)

Informacje prawne

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Temperatura zapłonu (°F): No data available
• Temperatura zapłonu (°C): No data available