Przejdź do zawartości
Merck

PRKCA

protein kinase C, alpha

Synonimy:
AAG6, PKC-alpha, PKCA, PRKACA
Gatunek:
Identyfikator UniProtKB:
Identyfikator genu:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha

Custom & Knockdown Gene Products

Small Molecule - Activator

Numer produktu
Opis
Gatunek
Aktywator lipidów PKC, ,
Gatunek
human

Small Molecule - Agonist

Numer produktu
Opis
Gatunek
Oleic acid, ≥99% (GC),
Gatunek
human

Antibodies

Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Przeciwciało anty-fosfo-PKCα (Ser657/Tyr658), Upstate®, from rabbit,
Reaktywność gatunkowa
human, rabbit, rat
Zastosowanie
ELISA
immunoprecipitation (IP)

western blot
Anti-PKC-PAN antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-PRKCA antibody produced in rabbit, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunofluorescence
immunohistochemistry

western blot
Anti-PRKCA antibody produced in rabbit, Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
immunofluorescence
immunohistochemistry

western blot
Przeciwciało anty-fosfo-PKC(pan) (gamma)-T514 wytwarzane u królika, ,
Reaktywność gatunkowa
human, mouse, rat
Zastosowanie
western blot

Small Molecule - Inhibitor

Numer produktu
Opis
Gatunek
D-Sphingosine, synthetic,
Gatunek
rat
1-Oleoyl-2-acetyl-sn-glycerol, ≥97% (TLC), oil,
Gatunek
human
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
Gatunek
rat, human
Bisindolylmaleimide IV, ≥98% (TLC), solid,
Gatunek
human, rat
(S)-(+)-Camptothecin, ≥90% (HPLC), powder,
Gatunek
rat, mouse, human

Proteins

Numer produktu
Opis
Gatunek
Białko PKCα, aktywne, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
Gatunek
human
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
Gatunek
human

esiRNA

Numer produktu
Opis
Gatunek
MISSION® esiRNA, targeting human PRKCA,
Gatunek
human
MISSION® esiRNA, targeting mouse Prkca,
Gatunek
mouse

Small Molecule - Substrate

Numer produktu
Opis
Gatunek
Peptyd substratu PKC, PKC Substrate Peptide primarily used in Kinase Assays.,
Gatunek
human