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方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 5 mg/mL, clear (warmed)
储存温度
−20°C
SMILES字符串
Clc1c(cccc1N2CCN(CC2)CCCCOc3cc4c(cc3)CCC(=O)N4)Cl
InChI
1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
InChI key
CEUORZQYGODEFX-UHFFFAOYSA-N
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一般描述
阿立哌唑的主要成分为 3, 4 二氢-2-(1H) 喹啉酮。[1]
应用
阿立哌唑已被用于研究其对乳腺肿瘤发生的影响，通过逆转录病毒传递受体酪氨酸蛋白激酶 2 或 HRas 原癌基因、gtp 酶或通过转基因表达 Wnt-1（原癌蛋白）介导。[2]也用于研究其对幼年自发性高血压大鼠的行为和神经化学作用。[3]
阿立哌唑已被用于研究阿立哌唑对注意缺陷多动障碍 (ADHD) 模型幼年自发性高血压大鼠 (SHR) 的行为和神经化学的影响。[4]
生化/生理作用
阿立哌唑是一种“多巴胺能稳定剂”。它被用作治疗精神分裂症患者的潜在治疗药物。此外，还最好用于治疗 Tourette 综合征 (TS) 患者的注意缺陷多动障碍 (ADHD)。[4]
特点和优势
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Neil M Richtand et al.
Physiology & behavior, 106(2), 171-177 (2012-02-22)
Studies characterizing treatment interventions in a naturalistic setting suggest that antidepressant and antipsychotic medications may be equally effective in improving clinical outcome in individuals at high risk for first-episode psychosis. Of interest, both beneficial as well as potentially adverse effects
Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: a longitudinal 1 H-NMR spectroscopy study at 11.7 T.
Rizzo F, et al.
Translational Psychiatry, 7(8), e1189-e1189 null
Hyperprolactinemia-inducing antipsychotics increase breast cancer risk by activating JAK-STAT5 in precancerous lesions.
Johnston A N, et al.
Breast Cancer Research, 20(1), 42-42 (2018)
D M Taylor
International journal of clinical practice, 57(1), 49-54 (2003-02-18)
Atypical antipsychotics generally have a lower propensity for extrapyramidal side-effects (EPSE), hyperprolactinaemia and tardive dyskinesia than that associated with typical antipsychotics but may still produce troublesome side-effects, such as weight gain, cardiac rhythm changes and impaired glucose tolerance. Aripiprazole is
Na Ye et al.
Current medicinal chemistry, 21(4), 437-457 (2013-10-30)
Psychiatric disorders like schizophrenia and neurodegenerative diseases like Parkinson's disease are associated with poly-factorial pathogenic mechanisms, with several neurotransmitter systems closely involved. In addition to the cerebral dopaminergic (DA) system, the serotoninergic (5-HT) system also plays a crucial role in
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