The recommended storage temperature for this material is ambient or room temperature. Studies have not been conducted to evaluate the stability or shelf life impact of the product when stored at other temperatures. In the original sealed container, the compound is quite stable at room temperature. Please see the link below to review additional information available in the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/366/380/r8875pis.pdf
价格与库存信息目前不能提供
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产品名称
鱼藤酮, ≥95%
方案
≥95%
沸点
210-220 °C/0.5 mmHg (lit.)
mp
159-164 °C (lit.)
SMILES字符串
COc1cc2OCC3Oc4c5C[C@@H](Oc5ccc4C(=O)C3c2cc1OC)C(C)=C
InChI
1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1
InChI key
JUVIOZPCNVVQFO-HBGVWJBISA-N
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一般描述
鱼藤酮属于类视黄醇家族。它天然存在于豆科植物中，并被认为具有细胞毒性。它常被用作杀虫剂。[1]
生化/生理作用
线粒体电子转运抑制剂。
鱼藤酮是烟酰胺腺嘌呤二核苷酸（NADH）：泛醌氧化还原酶线粒体电子传递的一种抑制剂。它能够很容易的通过节肢动物的外骨骼被吸收，但皮肤或哺乳动物的胃肠道的吸收则不佳。鱼藤酮作为一种神经毒素能产生帕金森样症状，从而作为一种动物模型用于作为病因和干预措施的研究。鱼藤酮的主要作用机制是通过抑制线粒体复合物Ⅰ造成氧化应激和氧化损伤。由于鱼藤酮的亲脂性，它可以渗入大脑，结合并抑制线粒体电子传递链(ETC)中的复合物Ⅰ。
制备说明
本品可以0.5 mg/ml溶于DMSO。其他信源表明它在DMSO的溶解度可达100 mM，但未经验证。
警示用语：
Danger
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
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For how long can the product maintain stability in powder form at 4 °C or -80 °C?
1 answer-
Helpful?
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Can aliquots of rotenone resuspended in DMSO be stored at -20C?
1 answer-
The solution stability has not been determined. However, a similar product, 557368, notes that "following reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C".
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What is the solubility in other compounds ?
1 answer-
This product is tested for solubility at 50 mg/mL in chloroform. Rotenone is poorly soluble in water at approximately 0.25-0.50 uM. Other options include Ethanol and DMSO.
Ethanol: 5 mg/mL (higher concentrations may be achieved with heat and sonication)
DMSO: 50 mg/mLHelpful?
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What's the solubility in DMSO
1 answer-
This product is soluble in DMSO at 0.5 mg/ml. Other sources suggest it can be dissolved in DMSO up to 100 mM, however this has not been verified.
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