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P4562

Sigma-Aldrich

丙酮酸钠

powder, BioXtra, suitable for mouse embryo cell culture

别名:

α酮基丙酸 钠盐, 2-氧代丙酸 钠盐, 丙酮酸 钠盐

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About This Item

线性分子式:
CH3COCOONa
CAS号:
113-24-6
分子量:
110.04
Beilstein:
3568341
EC 号:
204-024-4
MDL编号:
MFCD00002586
UNSPSC代码:
12352207
PubChem化学物质编号:
24898552
NACRES:
NA.75

产品线

BioXtra

质量水平

200

方案

≥99%

表单

powder

技术

cell culture | embryo: suitable

mp

>300 °C (lit.)

溶解性

H2O: 100 mg/mL

储存温度

2-8°C

SMILES字符串

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

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相关类别

一般描述

丙酮酸盐(pyruvate)，糖酵解通路的终产物，是丙酮酸(pyruvic acid)的阴离子形式。

应用

丙酮酸钠可用于：
  • 作为精子培养Ca2+ + N三羟甲基甲胺基乙磺酸(TES)–NaCl溶液的补充剂
  • 作为TCM-199 hepes改良溶液的补充剂，用于卵丘卵母细胞复合体(COC′s)培养
  • 作为杜氏改良Eagle培养基(DMEM)补充剂，用于培养小鼠原代肝细胞(MPH)，并用于腹腔注射禁食小鼠进行葡萄糖生成评估

生化/生理作用

丙酮酸钠主要用作培养基和肉汤组分。丙酮酸钠的抗氧化和抗炎作用可用于治疗过敏性鼻炎。丙酮酸钠还能用作乳酸中毒治疗的新药。
细胞将丙酮酸钠作为一种易于获取的碳水化合物来源。此外，它还参与氨基酸代谢并启动Kreb′循环。丙酮酸钠减弱体外氧化应激。 对于大多数细胞培养应用，应将100 mM溶液按1:100比例稀释。 该产品已被认证可用于小鼠胚胎培养。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H317,H319

危险分类

Eye Irrit. 2 - Skin Sens. 1B

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000411193
0000411194
0000411195
0000411194
0000411193

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L S Li et al.
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 31(2), 103-106 (2017-01-20)
Objective:Pyruvate is a key intermediate in several metabolic pathways of human body Sodium pyruvate possesses anti-oxidation and anti-inflammatory effects, which make it a possible novel therapy for allergic rhinitis. However, the relevant clinical research is rare. The aim of the
In vitro maturation of caprine oocytes in different concentrations of estrous goat serum
Kharche SD, et al.
Small Ruminant Research (2006)
Kyle S McCommis et al.
The Biochemical journal, 466(3), 443-454 (2015-03-10)
Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial enzymes that metabolize pyruvate are physically separated from cytosolic pyruvate pools and rely
Jing Yang et al.
Artificial cells, nanomedicine, and biotechnology, 44(1), 48-55 (2014-04-05)
To examine the effects of sodium pyruvate (SP) on metabolic acidosis. For the in vivo experiments, we evaluated effects of SP on an ammonium chloride (NH4Cl)-induced hyperchloremic acidosis rat model. SP was infused at overall doses of 2, 4, and
Maheul Ploton et al.
Journal of hepatology, 69(5), 1099-1109 (2018-07-08)
Embedded into a complex signaling network that coordinates glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver. Hepatic gluconeogenesis is controlled through allosteric regulation of gluconeogenic enzymes and by
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