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形狀
solid
顏色
yellow
溶解度
DMSO: 10 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
InChI
1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI 密鑰
QFWCYNPOPKQOKV-UHFFFAOYSA-N
基因資訊
human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)
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應用
PD 98,059已用于:
- 生长培养基,作为有丝分裂原活化蛋白(MAP)激酶抑制剂,以研究与D1样受体作用有关的次级信使
- 无钙RPMI(罗斯威尔公园纪念研究所)-1640培养基,结合囊性纤维化跨膜电导调节剂(CFTR)敲低,研究其对人表皮角质形成细胞系炎症、增殖和分化的影响
- 细胞迁移测定培养基
生化/生理作用
PD 98,059是一种类黄酮,同时是促分裂原活化蛋白激酶激酶(MAPKK)的特异性抑制剂。在小鼠体内,PD 98,059有助于阻断酵母聚糖刺激的器官功能障碍综合征和非败血性休克。目前确知它可抑制体外肥大。PD 98,059还诱导间充质基质细胞中的软骨形成。
法律資訊
经Warner Lambert公司许可出售。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
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PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase
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Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing
Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)
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