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化驗
≥98% (HPLC)
形狀
solid
顏色
faint yellow to dark orange
溶解度
DMSO: >10 mg/mL
H2O: insoluble
起源
GlaxoSmithKline
儲存溫度
2-8°C
SMILES 字串
[O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI
1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
InChI 密鑰
BGIYKDUASORTBB-UHFFFAOYSA-N
基因資訊
human ... MAPK14(1432)
一般說明
PD 169316是一种吡啶基咪唑化合物。它是p38丝裂原活化蛋白激酶的一种潜在抑制剂。它也对转化生长因子β(TGFβ)的信号转导进行抑制,特别是在人卵巢癌细胞中。
應用
PD 169316已被用于抑制人肝细胞中的p38酶。它已被用于在培养基中促进胚状体的分化。
生化/生理作用
有效的细胞通透型选择性p38激酶抑制剂(IC50 = 89 nM)。
特點和優勢
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表,单击此处。
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
Inhibition of p38 kinase mimics survival signal-linked protection against apoptosis in rat cerebellar granule neurons
Cellular & Molecular Biology Letters, 6(2), 173-184 (2001)
Activation of CD40 with platelet derived CD154 promotes reactive oxygen species dependent death of human hepatocytes during hypoxia and reoxygenation
PLoS ONE, 7(1), e30867-e30867 (2012)
A p38MAPK-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells
Cell Death & Disease, 4(7), e737-e737 (2013)
The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells
Biochemical and Biophysical Research Communications, 310(2), 391-397 (2003)
Arteriosclerosis, thrombosis, and vascular biology, 29(8), 1185-1192 (2009-05-23)
Motivated by the central roles that vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)-beta play in the assembly and maintenance of the vasculature, we examined the impact of systemic VEGF or TGF-beta signal inhibition on endothelial activation as
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