This product is intended for research and development purposes only and should not be used in drug or clinical applications.
价格与库存信息目前不能提供
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产品名称
左旋多巴, ≥98% (TLC)
方案
≥98% (TLC)
表单
powder
颜色
white to off-white
mp
276-278 °C (lit.)
应用
peptide synthesis
储存温度
room temp
SMILES字符串
N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O
InChI
1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
InChI key
WTDRDQBEARUVNC-LURJTMIESA-N
基因信息
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)
mouse ... DRD1(13488) , DRD2(13489) , DRD3(13490) , DRD4(13491) , DRD5(13492)
rat ... DRD1(24316) , DRD2(24318) , DRD3(29238) , DRD4(25432) , DRD5(25195)
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生化/生理作用
3,4-二羟基-L-苯丙氨酸或L-DOPA是多巴胺直接前体的一种天然异构体，它能穿过血脑屏障。它被应用于治疗帕金森疾病[3] ，是酪氨酸羟化酶的产物。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Effects of small-molecule amyloid modulators on a Drosophila model of Parkinson?s disease
Malgorzata Pokrzywa
PLoS ONE (2017)
Alan J. Sinclair, John E. Morley, Bruno Vellas
Pathy's Principles and Practice of Geriatric Medicine (2012)
Primary culture of human face skin melanocytes for the study of hyperpigmentation
Cytotechnology, 66(6) (2014)
Molly J Crockett et al.
Current biology : CB, 25(14), 1852-1859 (2015-07-07)
An aversion to harming others is a core component of human morality and is disturbed in antisocial behavior. Deficient harm aversion may underlie instrumental and reactive aggression, which both feature in psychopathy. Past work has highlighted monoaminergic influences on aggression
Sebastiaan P van Kessel et al.
Nature communications, 10(1), 310-310 (2019-01-20)
Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this study, we characterize gut-associated bacteria in their ability to decarboxylate levodopa to dopamine via tyrosine decarboxylases.
Chromatograms
application for HPLCapplication for HPLC-
Esta levodopa pode ser utilizada em processos de nanoencapsulamento para tratamento da doença de Parkinson?
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Hello I want to perform some enzyme activity assays with tyrosinase from mushroom , is this reagent suitable as a substrate to perform the assay by spectrophotometry? Thank you very much!
1 answer-
Yes, this product is used as a substrate in enzymatic analysis of product T3824, Tyrosinase from mushroom. This assay is performed to determine the polyphenol oxidase activity of the enzyme. The unit definition of Tyrosinase product is as follows:
One unit will cause a decrease in A265 of 0.001 per minute at pH 6.5 at 25 deg C. In a 3 mL reaction mixture containing L-Beta-3,4-dihydroxyphenyl-alanine (L-DOPA)Please see the link below to review a sample or lot-specific Certificate of Analysis for the T3824 Tyrosinase product to review this and additional substrates used to establish activity:
https://www.sigmaaldrich.com/product/sigma/t3824#product-documentationHelpful?
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I want to know the solvent, storage method, and storage period.
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As mentioned in the product Data Sheet, L-DOPA is slightly soluble in water (approximately 3.3 mg/ml) and in acidic and basic solutions. It is practically insoluble in ethanol. The stability of the product in solution has not been determined. See the statement below for further information. The recommended storage temperature is room temperature. Please view the datasheet for more information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/315/570/d9628pis.pdfSee the link below to a publication regarding the solution stability of L-Dopa that may be helpful:
https://pubmed.ncbi.nlm.nih.gov/8771063/This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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