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Merck

B7283

Sigma-Aldrich

多巴丝肼 盐酸盐

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

别名:

DL -丝氨酸 2-(2,3,4-三羟基苄基)酰肼 盐酸盐

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About This Item

经验公式(希尔记法):
C10H15N3O5 · HCl
CAS号:
分子量:
293.70
EC 号:
MDL编号:
UNSPSC代码:
12352125
PubChem化学物质编号:
NACRES:
NA.77
价格与库存信息目前不能提供

产品名称

多巴丝肼 盐酸盐, ≥98% (HPLC), solid

生物来源

synthetic

质量水平

方案

≥98% (HPLC)

表单

solid

溶解性

H2O: 10 mg/mL

创始人

Roche

储存温度

room temp

SMILES字符串

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

基因信息

human ... DDC(1644)

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一般描述

苄丝肼是一种外周脱羧酶抑制剂。[1]

应用

使用苄丝肼:
  • 抑制多巴脱羧酶[2]
  • 诱导运动障碍[3]
  • 测试纯化细菌TDC,以评估其对细菌脱羧酶的影响程度[4]
  • 作为外周多巴脱羧酶抑制剂治疗小鼠[5]

生化/生理作用

L -芳香族氨基酸脱羧酶抑制剂。
苄丝肼能够在体外阻断HK2酶活性。可与左旋多巴一同使用治疗帕金森氏症′。 [6]

特点和优势

该化合物由 Roche 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

24 - Extrapyramidal movement disorders and spasticity
Waller DG, et al.
Medical Microbiology, 325-336 (2018)
Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo
Goltsev Y, et al.
Developmental Biology, 330(2), 462-470 (2009)
Restoration of the dopamine transporter through cell therapy improves dyskinesia in a rat model of Parkinson?s Disease
Tomas D, et al.
PLoS ONE, 11(4), e0153424-e0153424 (2016)
Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson?s disease
van KSP, et al.
Nature Communications, 10(1), 310-310 (2019)
Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine
Tillerson JL, et al.
Experimental Neurology, 178, 80-90 (2002)

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Questions

  1. What is the recommended storage temperature for Benserazide hydrochloride (Product B7283) after the drug is suspended in water?

    1 answer
    1. Benserazide hydrochloride is soluble in water and should be dissolved in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. The solutions decompose on exposure to light and air. Benserazide HCl is a tan, photosensitive solid and should be stored tightly sealed at -4°C, protected from exposure to light. It is not recommended to store the aqueous solution for more than one day.

      Additionally, the product is subject to oxidation, and it is advisable to make solutions fresh daily. The product should be stored, as supplied, at room temperature for up to 1 year, and it should be protected from light.

      Helpful?

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