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Merck

D9378

Sigma-Aldrich

3,4-二羟基-D-苯丙氨酸

≥95% (TLC), powder, DOPA enantiomer

别名:

3-(3,4-二羟基苯)-D-丙氨酸, D-3-羟基酪氨酸, D-DOPA

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About This Item

经验公式(希尔记法):
C9H11NO4
CAS号:
分子量:
197.19
Beilstein:
2417637
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.32

product name

3,4-二羟基-D-苯丙氨酸, powder, ≥95%

化驗

≥95%

形狀

powder

mp

276-278 °C (lit.)

溶解度

1 M HCl: soluble
ethanol: insoluble

儲存溫度

−20°C

SMILES 字串

N[C@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m1/s1

InChI 密鑰

WTDRDQBEARUVNC-ZCFIWIBFSA-N

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應用

3,4-二羟基-D-苯丙氨酸(D-DOPA)已作为高效液相色谱法(HPLC)标准品,检测刺毛黎豆的发芽和原生种子粉中的L-DOPA。

生化/生理作用

3,4-二羟基-D-苯丙氨酸(D-DOPA)是DOPA的对映体,具有抗菌作用。D-DOPA可作为多巴胺合成的前体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Tomoya Kawazoe et al.
Chemical record (New York, N.Y.), 7(5), 305-315 (2007-10-10)
The flavoprotein D-amino acid oxidase (DAO) degrades the gliotransmitter D-Ser, a potent activator of N-methyl-D-aspartate-type glutamate receptors. A body of evidence suggests that DAO, together with its activator, G72 protein, may play a key role in the pathophysiology of schizophrenia.
Nan Lu et al.
Electrophoresis (2020-09-20)
This review summarizes recent developments (over the past decade) in the field of microfluidics-based solutions for enantiomeric separation and detection. The progress in various formats of microchip electrodriven separations, such as MCE, microchip electrochromatography, and multidimensional separation techniques, is discussed.
Mark H Burrell et al.
ACS chemical neuroscience, 6(11), 1802-1812 (2015-09-01)
Tonic dopamine (DA) levels influence the activity of dopaminergic neurons and the dynamics of fast dopaminergic transmission. Although carbon fiber microelectrodes and fast-scan cyclic voltammetry (FSCV) have been extensively used to quantify stimulus-induced release and uptake of DA in vivo
Philipp Hörmann et al.
Cell death discovery, 7(1), 151-151 (2021-07-07)
L-3,4-Dihydroxyphenylalanin (L-DOPA or levodopa) is currently the most used drug to treat symptoms of Parkinson's disease (PD). After crossing the blood-brain barrier, it is enzymatically converted to dopamine by neuronal cells and restores depleted endogenous neurotransmitter levels. L-DOPA is prone
Alessio Innocenti et al.
Bioorganic & medicinal chemistry letters, 19(13), 3430-3433 (2009-05-26)
An activation study of the membrane-associated carbonic anhydrase (CA, EC 4.2.1.1) isoform XV with a series of natural and non-natural amino acids and aromatic/heterocyclic amines is reported. Murine CA XV was strongly activated by some amino acids (d-Phe, l-/d-DOPA, d-Trp

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