A1774

阿米卡星 二硫酸盐

potency: 674-786 μg per mg (as amikacin base)

• 别名: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide disulfate, Antibiotic BB-K8 sulfate
• 经验公式（希尔记法）: C₂₂H₄₃N₅O₁₃ · 2H₂SO₄
• CAS号: 39831-55-5
• 分子量: 781.76
• Beilstein: 6172633
• EC 号: 254-648-6
• MDL编号: MFCD00167475
• UNSPSC代码: 51281632
• PubChem化学物质编号: 24890586
• NACRES: NA.85

属性

• 生物来源: synthetic
• 质量水平: 200
• 表单: powder or crystals
• 效能: 674-786 μg per mg (as amikacin base)
• 颜色: white to off-white
• 抗生素抗菌谱: Gram-negative bacteria; mycobacteria
• 作用机制: protein synthesis | interferes
• 储存温度: 2-8°C
• SMILES字符串: OS(O)(=O)=O.OS(O)(=O)=O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
• InChI: 1S/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1
• InChI key: FXKSEJFHKVNEFI-GCZBSULCSA-N

说明

一般描述

Chemical structure: aminoglycoside

应用

Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria [1]. It is used to study organism-directed delivery of antibiotics as well as drug resistance [2].

生化/生理作用

Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

其他说明

Keep container tightly closed in a dry and well-ventilated place.

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Warning
• 危险声明: H317,H361fd
• 预防措施声明: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313
• 危险分类: Repr. 2 - Skin Sens. 1
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable
• 个人防护装备: Eyeshields, Gloves, type N95 (US)