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Merck

A3650

Sigma-Aldrich

阿米卡星 水合物

aminoglycoside antibiotic

别名:

N 1 - [(S)-4-氨基-2-羟基丁酰基] 卡那霉素 A

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About This Item

经验公式(希尔记法):
C22H43N5O13 · xH2O
分子量:
585.60 (anhydrous basis)
Beilstein:
1445422
EC號碼:
MDL號碼:
分類程式碼代碼:
51281632
PubChem物質ID:
NACRES:
NA.85
价格与库存信息目前不能提供

生物源

synthetic

品質等級

形狀

powder

顏色

white to almost white

抗生素活性譜

Gram-negative bacteria
mycobacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

O.NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O

InChI

1S/C22H43N5O13.H2O/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);1H2/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1

InChI 密鑰

DTSOZYYWEZJFSS-XTHCGPPUSA-N

一般說明

化学结构:氨基糖苷类

應用

阿米卡星水合物用于对诸如 结核分枝杆菌 [1] 嗜艾利希体 等微生物的抗菌敏感性研究。[2]

生化/生理作用

阿米卡星通过与 30S 核糖体亚基结合,诱导 mRNA 误读,从而抑制细菌蛋白质合成。干扰 tRNA 从 A 位点到 P 位点的移位。[3]

包裝

5G

其他說明

保存于密闭容器内,置于干燥通风处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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H W Horowitz et al.
Antimicrobial agents and chemotherapy, 45(3), 786-788 (2001-02-22)
Human granulocytic ehrlichiosis is a recently described disease caused by an obligate intracellular gram-negative organism recently named Ehrlichia phagocytophila. To expand our knowledge of the susceptibility of E. phagocytophila, we tested six New York State isolates for susceptibility to 12
G J Alangaden et al.
Antimicrobial agents and chemotherapy, 42(5), 1295-1297 (1998-05-21)
An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 microg/ml). High-level cross-resistance may result from such a mutation since MTB has a
M P Goren et al.
The Pediatric infectious disease journal, 8(5), 278-282 (1989-05-01)
A three-drug antibiotic regimen including vancomycin and amikacin has been recommended as effective treatment in clinical settings in which Gram-positive bacteremias are a serious problem. To determine if vancomycin potentiates the tubular proteinuria associated with amikacin therapy, we studied febrile
Sophia B Georghiou et al.
PloS one, 7(3), e33275-e33275 (2012-04-06)
Rapid molecular diagnostics for detecting multidrug-resistant and extensively drug-resistant tuberculosis (M/XDR-TB) primarily identify mutations in Mycobacterium tuberculosis (Mtb) genes associated with drug resistance. Their accuracy, however, is dependent largely on the strength of the association between a specific mutation and
Hessel Van der Weide et al.
Antibiotics (Basel, Switzerland), 9(3) (2020-03-07)
Background: Recent scientific reports on the use of high dose tigecycline monotherapy as a "drug of last resort" warrant further research into the use of this regimen for the treatment of severe multidrug-resistant, Gram-negative bacterial infections. In the current study

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