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Merck

14400

Sigma-Aldrich

生物素

≥99.0% (T)

别名:

D-生物素, Bios II, 维生素B7, 维生素H, 辅酶 R

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About This Item

经验公式(希尔记法):
C10H16N2O3S
CAS号:
分子量:
244.31
Beilstein:
86838
EC 号:
MDL编号:
UNSPSC代码:
12352201
eCl@ss:
34058011
PubChem化学物质编号:
NACRES:
NA.21
价格与库存信息目前不能提供

生物来源

synthetic

质量水平

方案

≥99.0% (T)

表单

powder

旋光性

[α]20/D +91±2°, c = 1% in 0.1 M NaOH

灼烧残渣

≤0.1% (as SO4)

缺失

≤0.5% loss on drying

颜色

colorless to white

mp

229-234 °C
231-233 °C (lit.)

溶解性

alcohol: soluble 80mg/100 ml at 25 °C
water: soluble 22mg/100 ml at 25 °C
0.1 M NaOH: 10 mg/mL at 25 °C, clear, colorless
H2O: very soluble
organic solvents: insoluble

痕量阳离子

Ca: ≤50 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤10 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤500 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

应用

detection

SMILES字符串

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

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一般描述

生物素易从一些食物中获得,这些食物包括全谷物、坚果、豆类、糙米和蛋黄。正常肠道菌群也会产生这种维生素。[1]

应用

生物素已被用于检测展示亲和素的噬菌体的功能。[2]该产品还被用于标记猪抗兔 IgG 抗体和过氧化物酶。[3]

生化/生理作用

生物素也称为维生素 H 或维生素 B7,是一种水溶性 B 族维生素,可诱导大鼠肝脏、肾脏、结肠、小脑和心脏中鸟苷酸环化酶活性增加 2-3 倍。[4]还能刺激精子活力,延长冷冻保存的人体精子的存活时间。[5]
生物素是羧化酶的重要辅因子,存在于各种代谢途径。生物素有利于角蛋白的合成,因此用作头发和指甲生长的补充剂。生物素缺乏可表现出多种症状,如脱发、结膜炎、脂溢性皮炎、抑郁症、嗜睡、肌张力低下和癫痫发作等。[1]

其他说明

综述[6][7];亲和素-生物素技术;

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

M. Wilchek and E.A. Bayer, eds.
Methods of Enzymatic Analysis, 184 (1990)
H. Katsuki et al.
Antibiotics, Vitamins and Hormones (1977)
Guruprasad Kalthur et al.
Journal of assisted reproduction and genetics, 29(7), 631-635 (2012-04-25)
To study the effect of supplementing biotin to sperm preparation medium on the motility of frozen-thawed spermatozoa. Semen samples of men attending the University infertility clinic (n = 105) were cryopreserved using glycerol-egg yolk-citrate buffered cryoprotective medium in liquid nitrogen. After a
Tiina A Riihimäki et al.
BMC biotechnology, 11, 64-64 (2011-06-11)
Engineered proteins, with non-immunoglobulin scaffolds, have become an important alternative to antibodies in many biotechnical and therapeutic applications. When compared to antibodies, tailored proteins may provide advantageous properties such as a smaller size or a more stable structure. Avidin is
Biotin.
P N Murthy et al.
Progress in food & nutrition science, 2(9), 405-455 (1977-01-01)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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