Cycloheximide is commonly used to block protein synthesis in eukaryotic cells and in ribosome profiling experiments. It is recommended to refer to literature for further information, for example: https://pmc.ncbi.nlm.nih.gov/articles/PMC2831214/ and https://www.nature.com/articles/s41467-021-25411-y.
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About This Item
经验公式（希尔记法）:
C15H23NO4
CAS号:
分子量:
281.35
MDL编号:
UNSPSC代码:
41171614
PubChem化学物质编号:
NACRES:
NA.85
价格与库存信息目前不能提供
推荐产品
无菌性
sterile (Filtered and Aseptic Handled)
质量水平
表单
liquid
保质期
limited shelf life, expiry date on the label
浓度
0.1%
抗生素抗菌谱
fungi
应用
environmental
food and beverages
microbiology
储存温度
2-8°C
适用性
bacteria
SMILES字符串
O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
InChI
1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChI key
YPHMISFOHDHNIV-FSZOTQKASA-N
基因信息
human ... FKBP1A(2280) , PIN1(5300)
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一般描述
Cycloheximide solution is a selective supplement, that is safer and easier to use than cycloheximide powder. The required volume can be simply added to the medium before or after sterilization.
应用
Cycloheximide solution has been used as a supplement in De Man, Rogosa and Sharpe (MRS) and GM-17 agar plates to study its effects on lactic acid bacteria (LAB).
生化/生理作用
Cycloheximide solution is used to block the protein synthesis for suppressing the growth of fungi.
外形
含 0.1% 放线菌酮的无菌过滤溶液
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Can be used for ribosomal profiling, as a blocker of protein synthesis in eukaryotic cells?
1 answer-
Helpful?
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I am looking to add this solution to a Lee's Multi Differential Agar (LMDS) media solution to prevent saccharomyces cerevisiae growth on my plates. How much of this cycloheximide solution should be added per 100 ml of LMDA agar media?
1 answer-
According to brewing industry experts, cycloheximide can be added to Lee's Multi Differential Agar in order to make the media selective to bacteria and wild yeast. With cycloheximide, one can suppress the growth of most brewing yeasts without interfering with bacteria and wild yeast growth. Concentrations recommended for this purpose are in the range from 7-10 mg/L. Adding 10 mLs of product 18079 (at a concentration of 0.1%) to 1 L of agar will result in a concentration of 10 mg/L (a 1:100 dilution).
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