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T-075

Supelco

3,3′,5′-三碘代-甲腺原氨酸（rT3）标准液 溶液

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

别名:

3,3',5'-三碘- L -甲状腺氨酸, rT(3), 逆转 T 3

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About This Item

经验公式（希尔记法）:
C15H12I3NO4
CAS号:
5817-39-0
分子量:
650.97
MDL编号:
MFCD00036864
UNSPSC代码:
41116107
PubChem化学物质编号:
329826619
NACRES:
NA.24

等级

certified reference material

质量水平

300

表单

liquid

特点

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

制造商/商品名称

Cerilliant®

浓度

100 μg/mL in methanol with 0.1N NH3

技术

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

应用

clinical testing
clinical testing

包装形式

single component solution

储存温度

−20°C

SMILES字符串

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChI key

HZCBWYNLGPIQRK-LBPRGKRZSA-N

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相关类别

一般描述

反向T3，也称为rT3或3,3′,5′-三碘-L-甲状腺原氨酸，是甲状腺激素T3的一种生物失活形式，是在体内，特别是在压力期间产生的。在某些情况，如纤维肌痛、肝病和慢性疲劳综合症（CFS）时，更多的rT3会被产生，从而最大限度地减少所需要的甲状腺素（T4）向T3转化。通过LC-MS/MS测量反向T3血清浓度，以监测这些疾病和其他疾病对甲状腺激素水平的影响。

应用


  • 用于甲状腺研究的反向T3溶液：反向T3（3,3′,5′-三碘-L-甲腺原氨酸）可用于生化测定，用于评估甲状腺功能和代谢。作为甲状腺激素的非活性代谢产物，它在甲状腺激素平衡及其对代谢率的影响研究方面至关重要 （Filetti et al., 1980）。

  • 高纯度rT3甲状腺激素类似物：由于其高纯度和稳定性，反向T3（Reverse T3）对甲状腺代谢研究必不可少，为比较甲状腺活性和理解其在健康和疾病状态下生物学效应提供了可靠的标准。

  • 使用反向T3: rT3进行的甲状腺代谢研究有助于我们研究甲状腺激素代谢途径，特别是可以了解由T4变化为T3和rT3的转化过程，有助于破解甲状腺激素的复杂调节机制。

  • 比较内分泌学研究中的反向T3：反向T3溶液的应用可以扩展到比较内分泌学，用于研究不同物种之间甲状腺激素代谢的变化和相似性，有助于提供更广泛的生物学和进化的见解。

法律信息

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

靶器官

Eyes,Central nervous system

储存分类代码

3 - Flammable liquids

WGK

WGK 2

闪点(°F)

49.5 °F - closed cup

闪点(°C)

9.7 °C - closed cup

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Katarzyna Skórkowska-Telichowska et al.
Endokrynologia Polska, 63(4), 294-299 (2012-08-31)
Inhabitants living in areas with endemic dietary iodine intake deficiency develop nodular goitre. The aim of our study was to evaluate thyroid morphology and function among adults residing in Lower Silesia and to assess the effect on the thyroid gland
R Kassem et al.
Clinical and experimental dermatology, 37(8), 850-856 (2012-10-23)
Different elements of the hypothalamic-pituitary-thyroid axis have been found to be implicated in the normal physiology of the human skin. Their effects on wound healing and hair growth in rats have been described previously. There is close homology between the
Annemieke J Lem et al.
The Journal of clinical endocrinology and metabolism, 97(9), 3170-3178 (2012-06-28)
Age-appropriate reference ranges for thyroid hormones are required for detecting pediatric thyroid dysfunction. Data on thyroid hormones and peripheral thyroid metabolism in short children born small for gestational age (SGA) before and during GH treatment are lacking. Our objectives were
S Ruhla et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 43(2), 130-134 (2010-11-26)
Thyroid dysfunction has been shown to be associated with insulin resistance (IR). This may involve peripheral thyroid hormone metabolism, which is assumed to be reflected by the ratio triiodothyronine/reverse triiodothyronine (T3/rT3-ratio). To explore a potential association between the T3/rT3-ratio and
Ashley Hinther et al.
Environmental science & technology, 44(21), 8314-8321 (2010-10-12)
Nanometals are manufactured to particle sizes with diameters in the nanometer range and are included in a variety of consumer and health products. There is a lack of information regarding potential effects of these materials on aquatic organisms. Amphibians are
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实验方案

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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