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质量水平
方案
≥90%
表单
powder
储存温度
−20°C
SMILES字符串
OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
InChI
1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
InChI key
UOWZUVNAGUAEQC-UHFFFAOYSA-N
基因信息
human ... THRA(7067) , THRB(7068)
rat ... Thra(81812) , Thrb(24831)
应用
- 甲状腺激素研究：研究3,3′,5-三碘甲腺乙酸对MCT8缺陷患者的外周和神经发育影响，说明它的甲状腺相关发育疾病的治疗潜力(Unsal and Hayran, 2024)。
- 神经疾病治疗：研究用3,3′,5-三碘甲腺乙酸解决Allan-Herndon-Dudley综合征模拟大脑类器官的T3摄入和作用异常，为治疗大脑特异性甲状腺激素转运异常提供依据(Salas-Lucia et al., 2024)。
- 抗病毒治疗的药物发展：Tiratricol是3,3′,5-三碘甲腺乙酸的衍生物，研究发现它可通过靶向依赖病毒RNA的RNA聚合酶抑制黄热病毒复制，显示抗病毒药物开发潜力(Ren et al., 2023)。
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Napoleão F Valadares et al.
Bioorganic & medicinal chemistry, 15(13), 4609-4617 (2007-05-01)
2D QSAR studies were carried out for a series of 55 ligands for the Thyroid receptors, TRalpha and TRbeta. Significant cross-validated correlation coefficients (q(2)=0.781 (TRalpha) and 0.693 (TRbeta)) were obtained. The models' predictive abilities were proved more valuable than the
Christopher J Ryerson et al.
Journal of pain and symptom management, 43(4), 771-782 (2012-01-31)
Little is known about the treatment and correlates of dyspnea in idiopathic pulmonary fibrosis (IPF). The objective of this systematic review was to summarize the literature regarding the treatment and correlates of dyspnea in IPF. MEDLINE, EMBASE, and all Evidence-Based
Rie Anzai et al.
Thyroid : official journal of the American Thyroid Association, 22(10), 1069-1075 (2012-09-06)
The effectiveness of short-term 3,5,3'-triiodothyroacetic acid (TRIAC) therapy for the treatment of hyperthyroidism caused by thyroid hormone resistance (RTH) has been documented. Here, we report a 3-year course of TRIAC therapy in an RTH boy, with a quantitative evaluation of
Leandro Martínez et al.
Journal of medicinal chemistry, 49(1), 23-26 (2006-01-06)
Steered molecular dynamics simulations of ligand dissociation from Thyroid hormone receptors indicate that dissociation is favored via rearrangements in a mobile part of the LBD comprising H3, the loop between H1 and H2, and nearby beta-sheets, contrary to current models
Warren J L Wood et al.
Chembiochem : a European journal of chemical biology, 10(2), 361-365 (2008-12-24)
3-Iodothyronamine (T(1)AM) and 3,3',5-triiodothyroacetic acid (Triac) are bioactive metabolites of the hormone thyroxine (T(4)). In the present study, the ability of T(1)AM and 3,3',5-triiodothyronamine (T(3)AM) to be metabolized to 3-iodothyroacetic acid (TA(1)) and Triac, respectively, was investigated. Both T(1)AM and
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