C0289

Cholesteryl-Linoleat

≥98% (HPLC; detection at 205 nm)

• Synonym(e): 3β-Hydroxy-5-cholestene 3-linoleate, 5-Cholesten-3β-ol 3-linoleate, Cholesteryl 9,12-octadecadienoate, Cholesteryl octadecadienoate
• Empirische Formel (Hill-System): C₄₅H₇₆O₂
• CAS-Nummer: 604-33-1
• Molekulargewicht: 649.08
• EG-Nummer: 210-065-9
• MDL-Nummer: MFCD00003644
• UNSPSC-Code: 12352211
• PubChem Substanz-ID: 24892247
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: ≥98% (HPLC; detection at 205 nm)
• Form: powder
• Funktionelle Gruppe: ester
• Versandbedingung: ambient
• Lagertemp.: −20°C
• SMILES String: CCCCC\C=C/C\C=C/CCCCCCCC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@]4(C)[C@H](CC[C@H]4[C@@H]3CC=C2C1)[C@H](C)CCCC(C)C
• InChI: 1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
• InChIKey: NAACPBBQTFFYQB-LJAITQKLSA-N

Beschreibung

Anwendung

Cholesteryl linoleate was cosonicated with cholesterol to prepare dispersions were prepared to study the cholesterol to phospholipid ratio in red blood cell membrane. It was used as HPLC standard in the analysis of rat liver lipoproteins.

Biochem./physiol. Wirkung

Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.

The most abundant cholesteryl ester in low density lipoprotein (LDL).

Verpackung

verschweisste Ampulle

Angaben zur Herstellung

Cholesteryl linoleate yields clear, colorless solution in chloroform at 100 mg/ml.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)