T1952

Trichostatin A, Ready Made Solution

5 mM in DMSO, from Streptomyces sp.

• 동의어(들): TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
• 실험식(Hill 표기법): C₁₇H₂₂N₂O₃
• CAS Number: 58880-19-6
• Molecular Weight: 302.37
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: Streptomyces sp.
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: DMSO solution
• 농도: 5 mM in DMSO
• 기술: cell culture | mammalian: suitable
• 항생제 활성 스펙트럼: fungi; neoplastics
• 동작 모드: enzyme | inhibits
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: N(O)C(=O)\C=C\C(=C\C(C)C(=O)c1ccc(cc1)N(C)C)\C
• InChI: 1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
• InChI key: RTKIYFITIVXBLE-WKWSCTOISA-N

설명

일반 설명

Trichostatin A is a compound of primary hydroxamic acid.[1]

애플리케이션

Trichostatin A, ready-made solution has been used:

• as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing[2]
• to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)[3]
• to treat cells for the HDAC inhibition experiments[4]

생화학적/생리학적 작용

Trichostatin A (TSA) is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase at a nanomolar concentration and causes accumulation of highly acetylated histone molecules in mammalian cells. For that reason, trichostatin A is a tool to study the consequences of histone acetylation in vivo. Trichostatin A induces cell differentiation, cell cycle arrest, reversal of transformed cells morphology, and apoptosis and is able to modulate transcription. TSA has been used to establish a new cloning technique, which increases the success rates for mouse cloning.

Trichostatin A is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)