S9007

Spectinomycin dihydrochloride pentahydrate

potency: ≥603 μg per mg

• 동의어(들): Actinospectacin, Actinospectacin dihydrochloride pentahydrate, Spectinomycin, Spectinomycin HCL, Spectinomycin Hydrochloride, Spectinomycin hydrochloride
• 실험식(Hill 표기법): C₁₄H₂₄N₂O₇ · 2HCl · 5H₂O
• CAS Number: 22189-32-8
• Molecular Weight: 495.35
• EC Number: 244-554-3
• MDL number: MFCD00150886
• UNSPSC 코드: 51281666
• PubChem Substance ID: 24899822
• NACRES: NA.85

속성

• 생물학적 소스: synthetic (inorganic)
• Quality Level: 200
• 형태: powder
• 효능: ≥603 μg per mg
• 저장 조건: (Keep container tightly closed in a dry and well-ventilated place.)
• 색상: white to pale buff
• solubility: H₂O: soluble 50 mg/mL
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria
• 응용 분야: agriculture
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O
• InChI: 1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
• InChI key: DCHJOVNPPSBWHK-UXXUFHFZSA-N

설명

일반 설명

Chemical structure: aminoglycoside

애플리케이션

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

생화학적/생리학적 작용

Mode of Action: Spectinomycin acts by inhibiting protein synthesis and elongation by binding to the bacterial 30S ribosomal subunit and interfering with peptidyl tRNA translocation.

Mode of Resistance: A mutation in rpsE, the gene for ribosomal protein S5, prevents the binding of spectinomycin. Resistance is also conferred by the aminoglycoside-3′-adenyltransferase gene (aadA).

Antimicrobial spectrum: Spectinomycin acts against gram-negative and gram-positive bacteria.

주의사항

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

제조 메모

Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)