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주요 문서

303410

Sigma-Aldrich

Sodium butyrate

Sodium butyrate
1명의 제품 평가자(총 2명)가 샘플 제품을 받았거나 프로모션에 참여했습니다

98%

동의어(들):

Butyric acid sodium salt

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크기 선택

5 G
₩93,888
100 G
₩110,229
500 G
₩332,413

₩93,888


출고 가능일2025년 4월 24일세부사항


벌크 견적 요청

크기 선택

보기 변경
5 G
₩93,888
100 G
₩110,229
500 G
₩332,413

About This Item

Linear Formula:
CH3CH2CH2COONa
CAS Number:
Molecular Weight:
110.09
Beilstein:
3629439
EC Number:
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22

₩93,888


출고 가능일2025년 4월 24일세부사항


벌크 견적 요청

Quality Level

분석

98%

양식

powder

mp

250-253 °C (lit.)

SMILES string

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

InChI key

MFBOGIVSZKQAPD-UHFFFAOYSA-M

유전자 정보

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Sodium butyrate is the sodium salt form of butyric acid. It is a a natural compound known to inhibit tumor-cell growth and its biological activity in a human breast-cancer cell line (MCF7) was investigated.[1] Sodium butyrate may be an effective drug for the treatment of human spinal muscular atrophy patients.[2]

Sodium butyrate, an aliphatic sodium salt, serves as an acylating reagent for phenols.[3]

애플리케이션

Sodium butyrate can be used as a reactant to prepare butanal by reduction using 9-borabicyclo[3.3.1]nonane (9-BBN) in THF.[4] It is also converted into butanal borane and pyridinium chlorochromate by the reductive oxidation reaction.[5] Sodium butyrate is reacted with different alcohols to yield esters by Mitsunobu reaction using ionic liquid-based chloroiminium reagent.[6]

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Acylation of phenols to phenolic esters with organic salts
Zhang Z, et al.
Green Chemistry, 24(24), 9763-9771 (2022)
Exceptionally facile conversion of carboxylic acid salts to aldehydes by reductive oxidation with borane and pyridinium chlorochromate
Cha JS, et al.
Bull. Korean Chem. Soc., 22(3), 325-326 (2001)
Ionic Liquid Based Vilsmeier Reagent as a Substitute for Mitsunobu Reagent: Direct Conversion of Alcohols into Different Compounds under Ionic Liquid Conditions
Hullio AA and Mastoi GM
International Journal of Chemistry (Canadian Center of Science and Education), 5(3), 57-57 (2013)
D Coradini et al.
International journal of cancer, 81(3), 411-416 (1999-04-21)
The potential clinical utility of sodium butyrate, a natural compound known to inhibit tumor-cell growth, is hampered by the difficulty of achieving effective in-vivo concentrations. The short half-life (about 5 minutes) of sodium butyrate results in rapid metabolism and excretion.
J G Chang et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(17), 9808-9813 (2001-08-16)
Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by degeneration of the anterior horn cells of the spinal cord, leading to muscular paralysis with muscular atrophy. No effective treatment of this disorder is presently available. Studies of the

질문

1–4 / 4 질문  
  1. Can a stock solution be prepared in water or PBS, and how should it be stored?

    1 답변
    1. This material is appreciable soluble in water or aqueous buffers. Prepared solutions, when filter sterilized, are expected to be stable for up to 1 year at 2 - 8°C.

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. How can I determine the shelf life / expiration / retest date of this product?

    1 답변
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  4. What is the expected solubility in water?

    1 답변
    1. This product is soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7. 2 (~10 mg/ml).

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후기

1명의 제품 평가자(총 2명)가 샘플 제품을 받았거나 프로모션에 참여했습니다
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활성 필터

    • 상품평 1
    • 투표 21
    별 5개 중 2개입니다.

    Solubility problems with latest batch of sodium butyrate

    I had good experience with Sigma's sodium butyrate during the past few years but ran into solubility problems with the latest batch, BCCG8857. The newer batch has some sort of insoluble chemical mixed in with the sodium butyrate - possibly some caking/anti-caking regent?

    In the past, I have been able to consistently dissolve 300 mg/mL of sodium butyrate in water or PBS with outstanding results - the solution was perfectly clear and there are no signs of particles. With batch BCCG8857, there are numerous white insoluble particles even when dissolving the sodium butyrate at 60 mg /mL in water. The white insoluble particles tend to adhere near the surface after centrifugation and pellets on the side of the microcentrifuge tube rather than the bottom.

    Purchase the smaller sized bottles first to test the lot before making a bigger purchase (I was told there are no other/replacement lots until they go through most of the BCCG8857 lot).

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    1. Sigma-Aldrich Corporation의 답변:

      Thank you for taking the time to leave a review! We are sorry to hear that your experience did not meet expectations. We would like to learn more about your experience to see if there is anything we can do to help troubleshoot this issue. A member from our Technical Service Team will be contacting you shortly. Thank you again for your feedback.

    • 상품평 1
    • 투표 1
    별 5개 중 1개입니다.

    Not dissolving in water

    BCCG8857 batch is not dissolving in water. It has to be a batch problem because I've used this concentration (16 g/L) before without any issues.

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    1. Sigma-Aldrich Corporation의 답변:

      Solubility is not part of the specification for product 303410, it is not tested during quality control. However, due to a number of similar reports an investigation of lot BCCG8857 was performed and the remainder of the lot was removed from inventory. If you have not already, please contact us for a replacement free of charge by calling 1-800-325-5832.

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