B5887

Sodium butyrate

≥98.5% (GC)

• 동의어(들): Butyric acid sodium salt
• Linear Formula: CH₃CH₂CH₂COONa
• CAS Number: 156-54-7
• Molecular Weight: 110.09
• Beilstein: 3629439
• EC Number: 205-857-6
• MDL number: MFCD00002816
• UNSPSC 코드: 12352107
• PubChem Substance ID: 24891873
• NACRES: NA.25

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥98.5% (GC)
• 형태: powder
• 저장 조건: (Tightly closed. Dry.; Keep in a dry place. )
• 기술: DNA amplification: suitable; cell based assay: suitable; inhibition assay: suitable
• 색상: white
• mp: 250-253 °C (lit.)
• solubility: water: 100 mg/mL, clear to slightly hazy, colorless
• 양이온 미량물: Na: 19.8-22.0% (anhydrous)
• 적합성: suitable for DNA precipitation
• 응용 분야: cell analysis; life science and biopharma; lipidomics
• 저장 온도: room temp
• SMILES string: [Na+].CCCC([O-])=O
• InChI: 1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1
• InChI key: MFBOGIVSZKQAPD-UHFFFAOYSA-M
• 유전자 정보: mouse ... ENSMUSG00000061062(15181)

설명

애플리케이션

Sodium butyrate has been used:

• as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.
• as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.
• to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

생화학적/생리학적 작용

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range. Decreases Ca²⁺ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.

주의사항

Hygroscopic

기타 정보

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안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319
• 예방조치 성명서: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves