SRP0252
ULK Active human
recombinant, expressed in FreeStyle™ 293-F cells, ≥40% (SDS-PAGE)
동의어(들):
ATG1, ATG1 autophagy related 1 homolog, Serine/threonine-protein kinase ULK1, UNC-51-like kinase
로그인조직 및 계약 가격 보기
크기 선택
10 μG
₩1,111,933
₩1,111,933
구입 가능 여부는 고객센터에 문의하십시오.
모든 사진(1)
크기 선택
보기 변경
10 μG
₩1,111,933
About This Item
UNSPSC 코드:
12352200
NACRES:
NA.32
₩1,111,933
구입 가능 여부는 고객센터에 문의하십시오.
추천 제품
생물학적 소스
human
재조합
expressed in FreeStyle™ 293-F cells
분석
≥40% (SDS-PAGE)
양식
aqueous solution
분자량
113 kDa
포장
pkg of 10 μg
제조업체/상표
Invitrogen
저장 조건
avoid repeated freeze/thaw cycles
농도
>0.02 mg/mL
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... ULK1(8408)
일반 설명
ULK1 (unc-51 like autophagy activating kinase 1) is a Ser/Thr protein kinase which forms a component of the ULK1 protein kinase complex. This protein complex also contains the adaptor proteins ATG (autophagy-related) 13, RB1CC1/FIP200 (RB1-inducible coiled-coil 1), and ATG101. ULK1 protein is one of the five orthologs of yeast Atg1 found in mammals.[1]
생화학적/생리학적 작용
ULK1 (unc-51 like autophagy activating kinase 1) protein kinase plays a crucial role in the control of autophagy initiation. This protein is responsible for activating a cascade of signaling pathways which ultimately results in the formation of phagosomes. The phosphorylation of ULK1 by MTORC1 (mammalian target of rapamycin complex) leads to the negative regulation of autophagy.[1][2] Activation of type I interferon (IFN) receptor (IFNR) results in the activation of ULK1 protein, which, in turn, results in the transcription of gene in a IFN-stimulated response elements (ISRE) and IFNγ activation site (GAS) elements-mediated manner. It is also required for the control of the expression of key IFN-stimulated genes (ISGs).[3]
물리적 형태
Formulated in 2 5mM Tris-HCl, pH 7.5, 100 mM NaCl, 0.05% Tween-20, 100 μg/ml FLAG peptide, 20% glycerol and 3 mM DTT.
제조 메모
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
법적 정보
FreeStyle is a trademark of Invitrogen Corp.
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Computational analysis of an autophagy/translation switch based on mutual inhibition of MTORC1 and ULK1.
Szymanska P et al
PLoS ONE, 10(3), e0116550-e0116550 (2015)
Deubiquitinase inhibition by WP1130 leads to ULK1 aggregation and blockade of autophagy.
Autophagy, 11(9), 1458-1470 (2015)
Central role of ULK1 in type I interferon signaling.
Saleiro D et al
Cell Reports, 11(4), 605-617 (2015)
Pablo Sánchez-Martín et al.
Journal of cell science, 136(3) (2023-01-17)
Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly formed double-membrane structure called the autophagosome, and subsequently targeted for degradation in the lytic compartment of the cell. The fusion of autophagosomes with the lytic compartment
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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