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S7651

Sphingomyelinase from Bacillus cereus

Name: Sphingomyelinase from <I>Bacillus cereus</I>
Brand: SIGMA
Price: 175088 KRW

lyophilized powder, ≥100 units/mg protein

동의어(들):

Sphingomyelin choline phosphohydrolase, Sphingomyelin phosphodiesterase

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10 UNITS

₩175,088

50 UNITS

₩562,412

₩175,088

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보기 변경

10 UNITS

₩175,088

50 UNITS

₩562,412

About This Item

CAS Number:

9031-54-3

효소 위원회 번호:

3.1.4.12 (BRENDA, IUBMB)

EC Number:

232-869-9

MDL number:

MFCD00132362

UNSPSC 코드:

12352204

NACRES:

NA.54

₩175,088

구입 가능 여부는 고객센터에 문의하십시오.

추천 제품

Slide 1 of 10

1 of 10

Sigma-Aldrich

S8633

Sphingomyelinase from Staphylococcus aureus

Sigma-Aldrich

S9396

Sphingomyelinase from Bacillus cereus

Sigma-Aldrich

S0756

Sphingomyelin

Sigma-Aldrich

P6621

Phospholipase C from Bacillus cereus

Sigma-Aldrich

P7633

Phospholipase C from Clostridium perfringens (C. welchii)

Sigma-Aldrich

O1008

Oleic acid

Sigma-Aldrich

C7522

Calcium Ionophore A23187

Sigma-Aldrich

P8913

Phospholipase A₂ from bovine pancreas

Sigma-Aldrich

O1383

Oleic acid

Sigma-Aldrich

P8804

Phospholipase C, Phosphatidylinositol-specific from Bacillus cereus

양식

lyophilized powder

Quality Level

200

특이 활성도

≥100 units/mg protein

분자량

36873 Da

구성

Protein, ~10% Lowry

저장 온도

2-8°C

유전자 정보

Bacillus cereus ATCC 14579 ... BC0671(1203022)

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일반 설명

Sphingomyelinase from Bacillus cereus (Bc-Smase) is a Mg²⁺-containing metalloenzyme.[1] Bacillus cereus sphingomyelinase induces hemolysis of sheep erythrocytes.[2]

Sphingomyelinase modulates adenosine triphosphate (ATP)-independent endocytosis of fibroblast and large vesicles of macrophages.[3] Sphingomyelinase causes hemolysis of human erythrocytes. It is also a potent virulence factor leading to invasive diseases.[4]

애플리케이션

Sphingomyelinase from Bacillus cereus has been used:

in the measurement of membrane capacitance in brain slices[3]
for testing and confirming its silkworm-killing activity[4]
in enzyme activity assay and for elucidating its effect on hydrolysis of sphingomyelin in complex lipid mixtures[5]

Sphingomyelinase has been used in a study to investigate skeletal manifestations in pediatric and adult patients with Niemann Pick disease. [6]

생화학적/생리학적 작용

Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.

단위 정의

One unit will hydrolyze 1.0 μmole of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.

물리적 형태

Lyophilized powder containing potassium phosphate buffer salts and stabilizer.

픽토그램

GHS07

신호어

Warning

유해 및 위험 성명서

H317

예방조치 성명서

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 1

1 of 1

Sigma-Aldrich

SAE0044

Choline Oxidase from Arthrobacter sp.

Hemolysis induced by Bacillus cereus sphingomyelinase.

Masataka Oda et al.

Biochimica et biophysica acta, 1798(6), 1073-1080 (2010-03-11)

Bacillus cereus sphingomyelinase (Bc-SMase) induces hemolysis of sheep erythrocytes which contain large amounts of sphingomyelin. We investigated the mechanism of this hemolysis in comparison to that induced by Clostridium perfringens alpha-toxin. Pertussis toxin, a Gi-specific inhibitor, N-oleoylethernolamine, a ceramidase inhibitor

Lipid bilayers containing sphingomyelins and ceramides of varying N-acyl lengths: a glimpse into sphingolipid complexity

Jimenez-Rojo N, et al.

Biochimica et Biophysica Acta - Biomembranes, 1838(1), 456-464 (2014)

Skeletal manifestations in pediatric and adult patients with Niemann Pick disease type B.

Melissa Wasserstein et al.

Journal of inherited metabolic disease, 36(1), 123-127 (2012-06-22)

Niemann-Pick disease (NPD) due to acid sphingomyelinase deficiency is a lipid storage disease resulting from the accumulation of sphingomyelin, predominantly within cells of the monocyte-macrophage system. In contrast to other lysosomal storage disorders, skeletal involvement in NPD has not been

Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity

Usui K, et al.

Microbial Pathogenesis, 46(2), 59-62 (2009)

[Structure and function of sphingomyelinase].

Masataka Oda

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 129(10), 1233-1238 (2009-10-03)

Bacillus cereus is one that causes of opportunistic human infections. Sphingomyelinase produced by B. cereus is assumed a virulence factor for the infection. Sphingomyelinase from Bacillus cereus (Bc-SMase) is Mg(2+)-containing metalloenzyme. Bc-SMase is a family of neutral SMase (nSMase) and

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일년 전

Hi for product number S7651, Sphingomyelinase from Bacillus cereus, once prepared how long can the Sphingomyelinase solution be kept and should it be kept at 2-8C or -20C?

1 답변
1. Technical Support
  
  일년 전
  
  This product is stable for several days when stored refrigerated. Prepared solutions in aqueous buffers containing 50 % Glycerol are stable for extended periods when refrigerated.
  To review these product options please see the link below:
  https://www.sigmaaldrich.com/search/9031-54-3?focus=products&page=1&perpage=30&sort=relevance&term=9031-54-3&type=product
  
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주요 문서

Sphingomyelinase from Bacillus cereus

lyophilized powder, ≥100 units/mg protein

크기 선택

크기 선택

About This Item

추천 제품

속성

양식

Quality Level

특이 활성도

분자량

구성

저장 온도

유전자 정보

설명

일반 설명

애플리케이션

생화학적/생리학적 작용

단위 정의

물리적 형태

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

Flash Point (°F)

Flash Point (°C)

개인 보호 장비

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

이미 열람한 고객

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BiancaNeva

Hi for product number S7651, Sphingomyelinase from Bacillus cereus, once prepared how long can the Sphingomyelinase solution be kept and should it be kept at 2-8C or -20C?

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