P8014

4α-Phorbol 12,13-didecanoate

solid

• 동의어(들): 4α-Phorbol 12-13-dicaprinate, 4αPDD
• 실험식(Hill 표기법): C₄₀H₆₄O₈
• CAS Number: 27536-56-7
• Molecular Weight: 672.93
• Beilstein: 2514324
• MDL number: MFCD00036737
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24898900
• NACRES: NA.77

속성

• 양식: solid
• Quality Level: 100
• 색상: white
• solubility: DMSO: soluble; ethanol: soluble; methanol: soluble
• 저장 온도: −20°C
• SMILES string: CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC
• InChI: 1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
• InChI key: DGOSGFYDFDYMCW-OEFRVDPMSA-N

설명

애플리케이션

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:

• to study its effects on Madin-Darby canine kidney (MDCK) cells[1]
• to study its effects on Ca²⁺ influx in mice fallopian tubal cells[2]
• to study its effects on hind paw swelling in mice[3]

생화학적/생리학적 작용

4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.[4]

주의사항

Photosensitive

재구성

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

안전성 정보

• 픽토그램: GHS06,GHS08,GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330,H314,H317,H334,H351
• 예방조치 성명서: P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges