추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
저장 조건
desiccated
색상
white to tan
solubility
DMSO: ≥15 mg/mL
저장 온도
2-8°C
SMILES string
CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4
InChI
1S/C26H28F3N3O2/c1-19-23(25(33)30-22-10-5-9-21(17-22)26(27,28)29)18-24(20-7-3-2-4-8-20)32(19)12-6-11-31-13-15-34-16-14-31/h2-5,7-10,17-18H,6,11-16H2,1H3,(H,30,33)
InChI key
NCZYSQOTAYFTNM-UHFFFAOYSA-N
관련 카테고리
애플리케이션
HC-067047 has been used as a transient receptor potential cation channel subfamily V member 4 (TRPV4) inhibitor:
- to study its effects on organoid formation and proliferation in human endometrial tissues
- to determine its effects on neuronal survival after intracerebral hemorrhage (ICH)
- to study its effects on TRPV4 regulation of angiotensin II receptor type 1 (AT1R) task, phosphorylation and β-arrestin recruitment in choroid plexus
생화학적/생리학적 작용
HC-067047 is a potent, selective inhibitor of hTRPV4. The compound inhibits human, rat and mouse TRPV4 with IC50 values of 48, 133 and 17 nM, respectively. HC-067047 does not inhibit other TRPV isoforms at concentrations up to 5 μM. HC-067047 inhibits hERG channel and the menthol receptor TRPM8 with IC50 values of 370 and 780 nM, respectively.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Lihua Ying et al.
Science translational medicine, 7(319), 319ra204-319ra204 (2015-12-25)
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Science advances, 5(7), eaaw7243-eaaw7243 (2019-07-30)
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American journal of physiology. Renal physiology, 313(5), F1136-F1148 (2017-08-05)
Myogenic response, a phenomenon in which resistance size arteries and arterioles swiftly constrict or dilate in response to an acute elevation or reduction, respectively, in intravascular pressure is a key component of renal autoregulation mechanisms. Although it is well established
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Journal of cellular physiology, 235(5), 4443-4454 (2019-10-20)
Aquaporin-2 (AQP2) promotes renal cell migration by the modulation of integrin β1 trafficking and the turnover of focal adhesions. The aim of this study was to investigate whether AQP2 also works in cooperation with Na+ /H+ exchanger isoform 1 (NHE1)
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