P5514

Pyrilamine maleate salt

• 동의어(들): Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-N′,N′-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt
• 실험식(Hill 표기법): C₁₇H₂₃N₃O · C₄H₄O₄
• CAS Number: 59-33-6
• Molecular Weight: 401.46
• EC Number: 200-422-7
• MDL number: MFCD00069333
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24277797
• NACRES: NA.77

속성

• 양식: powder
• 주관자: Watson
• SMILES string: OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
• InChI: 1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
• InChI key: JXYWFNAQESKDNC-BTJKTKAUSA-N
• 유전자 정보: human ... HRH1(3269)

설명

애플리케이션

Pyrilamine maleate salt has been used:

• to treat Cassiopea sp. as H₁ receptor antagonist[1]
• to intraperitoneally inject mice to prevent the release of endogenous histamine[2]
• in membrane binding assay to determine the K_i values and in the comparative inhibitory concentration (IC₅₀) studies by whole-cell patch clamp technique[3]

생화학적/생리학적 작용

Pyrilamine maleate is a H1 histamine receptor antagonist. Pyrilamine maleate induces sleep in vertebrates. In Cassiopea, it induces concentration dependent dormancy.[1]

특징 및 장점

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H335
• 예방조치 성명서: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves