P6126

(R)-(−)-Phenylephrine hydrochloride

≥99% (titration), powder, α₁-adrenoceptor agonist

• 동의어(들): (R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride
• Linear Formula: HOC₆H₄CH(CH₂NHCH₃)OH·HCl
• CAS Number: 61-76-7
• Molecular Weight: 203.67
• Beilstein: 4158948
• EC Number: 200-517-3
• MDL number: MFCD00012605
• UNSPSC 코드: 12352200
• PubChem Substance ID: 57654535
• NACRES: NA.77

속성

• 제품명: (R)-(−)-Phenylephrine hydrochloride, powder
• 양식: powder
• Quality Level: 200
• mp: 143-145 °C (lit.)
• 주관자: Johnson & Johnson
• SMILES string: OC1=CC([C@H](CNC)O)=CC=C1.Cl
• InChI: 1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
• InChI key: OCYSGIYOVXAGKQ-FVGYRXGTSA-N
• 유전자 정보: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)

설명

일반 설명

(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.[1]

애플리케이션

(R)-(-)-Phenylephrine hydrochloride has been used:

• in the preparation and culturing of cardiocytes and fibroblasts[2]
• to stimulate myocardial strips to measure slice contraction[3]
• in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo[4]
• to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes[5]
• to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality[6]

생화학적/생리학적 작용

α₁-adrenoceptor agonist.

특징 및 장점

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H317
• 예방조치 성명서: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1B
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves