추천 제품
생물학적 소스
mouse
Quality Level
결합
unconjugated
항체 형태
ascites fluid
항체 생산 유형
secondary antibodies
클론
HP-6002, monoclonal
포함
15 mM sodium azide
기술
indirect ELISA: 1:2,000
동형
IgG1
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
관련 카테고리
일반 설명
IgG is the main antibody type found in plasma and extracellular fluid and is expressed on B cell membrane. IgG is further subdivided into four subclass- IgG1, IgG2, IgG3 and IgG4 and contribute 65, 30, 5 and 4% in total IgG. IgG2 produce in response to anti-polysaccharide. Monoclonal anti-human IgG2 (Fc specific) antibody can be used in indirect ELISA and Immunofluorometric Assay (IFMA). Mouse anti-human IgG2 (Fc specific) antibody reacts specifically with IgG2 of human but not with other IgG subclasses.
특이성
Monoclonal Anti-Human IgG2 is specific for the IgG2 subclass and nonreactive with IgG1, IgG3, and IgG4 in an ELISA.
면역원
Purified human IgG myeloma proteins covalently linked to polyaminostyrene microbeads.
애플리케이션
Monoclonal Anti-Human IgG2 (Fc specific) antibody is suitable for use in ELISA[1].
Monoclonal anti-human IgG2 (Fc specific) antibody can be used to detect IgG2 subclass by using different immunoassays like- hemagglutination (HA), hemagglutination inhibition(HAI), Imprint Immunofixation (IIF) and Particle Counting Immunoassay (PACIA). It can also be used in immunohistological assays.
생화학적/생리학적 작용
IgG2 immunoglobulin is a 146 kDa IgG subtype, which mediates immune response to the polysaccharide antigens of the bacterial capsule. Deficiency of IgG2 poses an increased risk to certain bacterial infections. IgG2 has the least affinity among the IgG subtypes to Fcγ receptors (FcγR). IgG2 exists in three forms namely, IgG2-A, -B, and -A/B. They show variation in the arrangement of fragment antigen binding domain (Fab) and hinge region.
물리적 형태
This product is provided as ascites fluid with 15 mm sodium azide as a preservative.
저장 및 안정성
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Human IgG2 antibodies display disulfide-mediated structural isoforms.
Wypych J, et al.
The Journal of Biological Chemistry, 283(23), 16194-16205 (2008)
A Macpherson et al.
Gut, 38(3), 365-375 (1996-03-01)
In contrast with normal subjects where IgA is the main immunoglobulin in the intestine, patients with active inflammatory bowel disease (IBD) produce high concentrations of IgG from intestinal lymphocytes, but the antigens at which these antibodies are directed are unknown.
Issa Nebie et al.
Infection and immunity, 76(2), 759-766 (2007-12-12)
There is longstanding evidence that immunoglobulin G (IgG) has a role in protection against clinical malaria, and human antibodies of the cytophilic subclasses are thought to be particularly critical in this respect. In this cohort study, 286 Burkinabè children 6
Sodiomon B Sirima et al.
PloS one, 4(10), e7549-e7549 (2009-10-27)
A Phase Ia trial in European volunteers of the candidate vaccine merozoite surface protein 3 (MSP3), a Plasmodium falciparum blood stage membrane, showed that it induces biologically active antibodies able to achieve parasite killing in vitro, while a phase Ib
Philippe A Denoël et al.
Clinical and vaccine immunology : CVI, 14(10), 1362-1369 (2007-08-19)
It has been repeatedly observed that mixing Haemophilus influenzae type b (Hib) conjugate vaccines with acellular pertussis-containing vaccines (diphtheria-tetanus-acellular pertussis [DTPa]) resulted in a reduced magnitude of the anti-polyriboseribitolphosphate antibody response compared to that obtained when Hib vaccines were administered
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