추천 제품
분석
98%
mp
183-185 °C (lit.)
작용기
aldehyde
chloro
ketone
SMILES string
Cc1cc2OC=C(C=O)C(=O)c2cc1Cl
InChI
1S/C11H7ClO3/c1-6-2-10-8(3-9(6)12)11(14)7(4-13)5-15-10/h2-5H,1H3
InChI key
NULJNFUEBPQUNB-UHFFFAOYSA-N
유전자 정보
human ... PTPN1(5770)
일반 설명
6-Chloro-3-formyl-7-methylchromone (6-Chloro-7-methyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde) is a benzopyran derivative. It is a bicyclic heterocyclic molecule made up of a benzene ring fused to a heterocyclic pyran ring.
애플리케이션
6-Chloro-3-formyl-7-methylchromone is the suitable reagent used in a study to investigate the multidrug resistabnce reversal by some 3- formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene.[1] It is the suitable reagent used in the synthesis of uridine-based library.[2]
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
Howard C Hang et al.
Chemistry & biology, 11(3), 337-345 (2004-05-05)
The polypeptide N-acetyl-alpha-galactosaminyltransferases (ppGalNAcTs, also abbreviated ppGaNTases) initiate mucin-type O-linked glycosylation and therefore play pivotal roles in cell-cell communication and protection of tissues. In order to develop new tools for studying mucin-type O-linked glycosylation, we screened a 1338 member uridine-based
Zoltán Baráth et al.
In vivo (Athens, Greece), 20(5), 645-649 (2006-11-10)
Several new 3-formylchromone derivatives proved to be modifiers of multidrug resistance in mouse lymphoma cells and in human Colo320 colon cancer cells. There is apparently a structure-activity relationship between the antiproliferative multidrug resistance-reversing effect and the chemical structure of the
Juan Zhang et al.
The Analyst, 140(16), 5716-5723 (2015-07-15)
Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the treatment of type 2 diabetes and obesity, so a colorimetric method has been developed in this work for PTP1B assay and screening of its inhibitors. The method is
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