- [Updates on rickets and osteomalacia: various roles of Klotho and FGF23 in vivo ].
[Updates on rickets and osteomalacia: various roles of Klotho and FGF23 in vivo ].
Clinical calcium (2013-10-01)
Akihiro Imura
PMID24076646
要旨
Recent understandings of phosphate regulation have, at least in part, depended upon the findings of fibroblast growth factor (FGF) 23, the hormone specific for phosphate regulation. Moreover, FGF23 would be the most important marker for prognosis in chronic kidney disease (CKD) . On the other hand, Klotho was firstly developed as a responsible gene for senescence. Although the role of Klotho has been so far established as a co-receptor for FGF23 in mineral metabolism, Klotho would play rather various roles than FGF23 signaling. Thus Klotho is not necessarily equivalent to FGF23. Further studies for both Klotho and FGF23 will elucidate to understand mineral homeostasis.
材料
製品番号
ブランド
製品内容
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, Type IX-A, lyophilized powder, 1,000,000-5,000,000 units/g protein (30 min assay)
Sigma-Aldrich
β-グルクロニダーゼ from Helix pomatia, Type H-1, partially purified powder, ≥300,000 units/g solid
Sigma-Aldrich
β-グルクロニダーゼ from Helix pomatia, Type H-5, lyophilized powder, ≥400,000 units/g solid
Sigma-Aldrich
β-グルクロニダーゼ カサガイ（Patella vulgata）由来, Type L-II, lyophilized powder, 1,000,000-3,000,000 units/g solid
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, Type VII-A, lyophilized powder, 5,000,000-20,000,000 units/g protein, pH 6.8 (30 min assay)
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, >20,000,000 units/g protein, recombinant, expressed in E. coli, aqueous glycerol solution
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, ≥20,000 units/mg protein, recombinant, expressed in E. coli overproducing strain, lyophilized powder
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, ≥10,000,000 units/g protein (30 min assay), recombinant, expressed in E. coli overproducing strain, lyophilized powder
Sigma-Aldrich
β-グルクロニダーゼ 大腸菌由来, aqueous glycerol solution, ≥5,000,000 units/g protein, pH 6.8 (biuret)