1188800

ジクロフェナク ナトリウム塩

United States Pharmacopeia (USP) Reference Standard

• 別名: 2-[(2,6-ジクロロフェニル)アミノ]ベンゼン酢酸 ナトリウム塩
• 実験式（ヒル表記法）: C₁₄H₁₀Cl₂NNaO₂
• CAS番号: 15307-79-6
• 分子量: 318.13
• MDL番号: MFCD00082251
• UNSPSCコード: 41116107
• PubChem Substance ID: 329749565
• NACRES: NA.24

特性

• グレード: pharmaceutical primary standard
• APIファミリー: diclofenac
• メーカー／製品名: USP
• アプリケーション: pharmaceutical (small molecule)
• フォーマット: neat
• SMILES記法: [Na+].[O-]C(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
• InChI: 1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
• InChI Key: KPHWPUGNDIVLNH-UHFFFAOYSA-M
• 遺伝子情報: human ... PTGS1(5742) , PTGS2(5743)

詳細

詳細

Diclofenac sodium is a sodium salt of diclofenac, a non-steroidal anti-inflammatory drug (NSAID). It prevents the synthesis of prostaglandin involved in pain, inflammation, and fever by inhibiting the cyclooxygenase enzyme activity.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

アプリケーション

Diclofenac sodium USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare acid stage standard, standard, standard stock, sensitivity, and system suitability solution for the assay, impurity analysis, identification, and performance test by using liquid chromatography coupled with UV detector according to the given below monographs of United States Pharmacopeia (USP): 

• Diclofenac Sodium
• Diclofenac Sodium Delayed-Release Tablets  
• Diclofenac Sodium Extended-Release Tablets
• Diclofenac Sodium Topical Solution
• Diclofenac Sodium and Misoprostol Delayed-Release Tablets

生物化学的／生理学的作用

標準的なNSAIDかつシクロオキシゲナ-ゼ (COX) 阻害剤です。主要代謝産物は4´-ヒドロキシジクロフェナクおよび5´-ヒドロキシジクロフェナクです。CYP2C9に特異的な基質として用いられてきました。

アナリシスノート

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

その他情報

Sales restrictions may apply.

安全性情報

• ピクトグラム: GHS06,GHS08,GHS09
• シグナルワード: Danger
• 危険有害性情報: H301,H361d,H372,H411
• 注意書き: P202 - P260 - P264 - P270 - P273 - P301 + P310
• 危険有害性の分類: Acute Tox. 3 Oral - Aquatic Chronic 2 - Repr. 2 - STOT RE 1
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable