SRP8009

GITRL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >90% (SDS-PAGE)

• 別名: AITRL, TNFSF18
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: mouse
• リコンビナント: expressed in HEK 293 cells
• タグ: FLAG^® tagged
• アッセイ: >90% (SDS-PAGE)
• フォーム: liquid
• 分子量: ~22 kDa by SDS-PAGE
• 包装: pkg of 50 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 濃度: ≥0.2 mg/mL
• 不純物: <0.1 EU/μg endotoxin, tested
• 色: clear
• UniProtアクセッション番号: Q7TS55
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: mouse ... Tnfsf18(240873)

詳細

詳細

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

物理的形状

Solution in 10 mM glycine, pH 10.0.

その他情報

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG^®-tag.

法的情報

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable