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由来生物
human
リコンビナント
expressed in E. coli
アッセイ
≥95% (HPLC)
≥95% (SDS-PAGE)
形状
lyophilized
有効性
≥0.5 ng/mL
分子量
19.7 kDa
包装
pkg of 25 μg
不純物
<0.1 EU/μg endotoxin, tested
色
white to off-white
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... FGF4(2249)
詳細
The FGF4 (fibroblast growth factor 4) gene is mapped to human chromosome 11q13.3. It is expressed during early embryonic development. In adults, it is strongly expressed in the testis. The encoded protein mainly interacts with FGFR1c (FGF receptor 1c) and FGFR2c. It also binds to FGFR3c and FGFR4, but to a lesser extent.
アプリケーション
- FGF-4 human has been used to study the effect of FGF4 on the differentiation of PDMCs (placenta-derived multipotent cells) into hepatocyte-like cells.
- It has been used as a growth factor to study the proliferation and differentiation of human bone marrow mesenchymal stem cells (hMSCs) to chondrocytes.
- It has been used to study hepatic differentiation.
生物化学的／生理学的作用
FGF4 (fibroblast growth factor 4) was first identified as an oncogene transforming NIH3T3 (mouse embryo fibroblast cell line) cells. It helps in maintaining the self-renewal capability of normal stem cells (for instance, trophoblastic stem cells). It is also required for cellular differentiation, morphogenesis and proliferation. It controls proliferation and differentiation of normal stem cells, progenitor cells and cancer cells.
物理的形状
Lyophilized from 10 mM Sodium Phosphate, pH 7.6 + 100 mM NaCl.
再構成
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP3261-25UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Grillo L, et al.
Gene, 534, 435-435 (2014)
Isolation and characterization of epithelial progenitor cells from human fetal liver.
Liu YN, et al.
Hepatology Research : the Official Journal of the Japan Society of Hepatology, 38, 103-103 (2008)
Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Yasuda K, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 94, 1355-1355 (2014)
Chondrogenic induction of human mesenchymal stem cells using combined growth factors for cartilage tissue engineering.
Bosetti M, et al.
Journal of Tissue Engineering and Regenerative Medicine, 6, 205-205 (2012)
Eryn Wicklow et al.
PLoS genetics, 10(10), e1004618-e1004618 (2014-10-24)
Pluripotent epiblast (EPI) cells, present in the inner cell mass (ICM) of the mouse blastocyst, are progenitors of both embryonic stem (ES) cells and the fetus. Discovering how pluripotency genes regulate cell fate decisions in the blastocyst provides a valuable
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