SRP0463

BRD4, BD1, BD2 (49-460) GST tag human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• 別名: CAP, HUNK1, HUNKI, MCAP, bromodomain containing 4
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥80% (SDS-PAGE)
• フォーム: aqueous solution
• 分子量: 73.3 kDa
• 包装: pkg of 100 μg
• NCBIアクセッション番号: NM_058243
• UniProtアクセッション番号: O60885
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... BRD4(23476)

詳細

詳細

BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker.[1][2]
Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_ NM_058243) amino-acids 49-460 with N-terminal GST-tag, MW = 73.3kDa, expressed in an Escherichia coli expression system.

生物化学的／生理学的作用

BRD4 (bromodomain-containing protein 4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease.[1][2] This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis.[2] BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II.[3]

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable