SML3473

144DG11

≥98% (HPLC)

• 別名: 1,2-Dihydro-N-(2-methoxyethyl)-6-methyl-N-[(3-methyl-2-thienyl)methyl]-2-oxo-4-pyridinecarboxamide, 2-Hydroxy-N-(2-methoxyethyl)-6-methyl-N-((3-methylthiophen-2-yl)methyl)isonicotinamide
• 実験式（ヒル表記法）: C₁₆H₂₀N₂O₃S
• CAS番号: 1257155-76-2
• 分子量: 320.41
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder or solid
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear (Warmed)
• アプリケーション: research use
• 保管温度: 2-8°C
• SMILES記法: OC1=NC(C)=CC(C(N(CCOC)CC2=C(C)C=CS2)=O)=C1
• InChI Key: BBEZNLRXWCUHAJ-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

144DG11 is a polyglucosan (PG)-reducing agent that targets the lysosomal membrane protein LAMP1 and increases autophagic flux in adult polyglucosan body disease (APBD) primary fibroblasts (50 μM for 24 hrs), resulting in an enhanced glycophagy, respiratory and glycolytic ATP production. 144DG11 prolongs survival and improves motor parameters of Gbe(ys/ys) mice in vivo (250 mg/150 μL/kg 2x per wk via i.v. for 1 month, then s.c.), a murine APBD model, by reducing PG and glycogen levels in brain, liver, heart, and peripheral nerve with good pharmacokinetic properties and no adverse effects to the animals.

Polyglucosan (PG)-reducing agent that targets the lysosomal membrane protein LAMP1 in cultures and in vivo.

免責事項

For research use only

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable