SML1227

Tavaborole

≥95% (HPLC)

• 別名: 1,3-ジヒドロ-5-フルオロ-1-ヒドロキシ-2,1-ベンゾオキサボロール, 5-フルオロ-1,3-ジヒドロ-1-ヒドロキシ-2,1-ベンゾオキサボロール, AN-2690, AN2690
• 実験式（ヒル表記法）: C₇H₆BFO₂
• CAS番号: 174671-46-6
• 分子量: 151.93
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: B1(OCc2c1ccc(c2)F)O
• InChI: 1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
• InChI Key: LFQDNHWZDQTITF-UHFFFAOYSA-N

詳細

詳細

Tavaborole is a boron-based pharmaceutical agent. It has broad-spectrum oxaborole antifungal activity. Due to its low molecular weight, it facilitates maximal nail plate penetration than its predecessors.[1][2][3]

生物化学的／生理学的作用

Tavaborole (AN2690) is a potent antifungal that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS).

Tavaborole (AN2690) is a potent antifungal that targets the post-transfer editing site of leucyl-tRNA synthetase (LeuRS). Tavaborole forms a covalent adduct with the 3′ adenosine of tRNA(leu) at the editing site of fungal, but not bacterial LeuRS, locking the enzyme in an inactive conformation. Tavaborole was recently approved for the treatment of onychomycosis of the toenail in adults.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable