SML0664

LM11A-31 dihydrochloride

≥95% (HPLC)

• 別名: 2-Amino-3-methyl-N-[2-(4-morpholinyl)ethyl]-pentanamide dihydrochloride
• 実験式（ヒル表記法）: C₁₂H₂₅N₃O₂ · 2HCl
• CAS番号: 1214672-15-7
• 分子量: 316.27
• MDL番号: MFCD11505486
• UNSPSCコード: 51111800
• PubChem Substance ID: 329825578
• NACRES: NA.77

特性

• アッセイ: ≥95% (HPLC)
• フォーム: oil
• 保管条件: desiccated
• 色: colorless to yellow
• 保管温度: 2-8°C
• SMILES記法: Cl.Cl.CCC(C)C(N)C(=O)NCCN1CCOCC1
• InChI: 1S/C12H25N3O2.2ClH/c1-3-10(2)11(13)12(16)14-4-5-15-6-8-17-9-7-15;;/h10-11H,3-9,13H2,1-2H3,(H,14,16);2*1H
• InChI Key: LLIHJRRZJDEKLB-UHFFFAOYSA-N

詳細

アプリケーション

LM11A-31 dihydrochloride has been used to study the effect of p75 neurotrophin receptor (p75 NTR) blockade, by non-peptide LM11A-31 ligand, on PC12 cell viability.[1]

生物化学的／生理学的作用

LM11A-31 is a non-peptide ligand of the p75 neurotrophin receptor (p75NTR). LM11A-31 blocks pro-NGF induced cell death in neuronal cultures, and protects neuronal cells from the the cytotoxic effects of cisplatin or methotrexate. Oral administration of LM11A-31 promotes the survival of oligodendrocytes and myelinated axons in a mouse spinal cord injury model and improves function in both weight-bearing and non-weight bearing tests.

LM11A-31 is a p75 neurotrophin receptor (p75NTR) ligand.

安全性情報

• ピクトグラム: GHS07,GHS09
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335,H410
• 注意書き: P273 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable