SMB00387

Prothionamide

≥99% (HPLC)

• 別名: Prothionamide, 2-propyl-4-pyridinecarbothioamide, 2-propylisonicotinylthioamide, 2-propylthioisonicotinamide, 2-Propyl-4-pyridinecarbothioamide, 2-Propylisonicotinylthioamide
• 実験式（ヒル表記法）: C₉H₁₂N₂S
• CAS番号: 14222-60-7
• 分子量: 180.27
• MDL番号: MFCD00464119
• UNSPSCコード: 51102829
• PubChem Substance ID: 329824982
• NACRES: NA.85

特性

• アッセイ: ≥99% (HPLC)
• 形状: powder
• 色: yellow
• 抗生物質活性スペクトル: mycobacteria
• 作用機序: enzyme | interferes
• 保管温度: −20°C
• SMILES記法: NC(C1=CC(CCC)=NC=C1)=S
• InChI: 1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
• InChI Key: VRDIULHPQTYCLN-UHFFFAOYSA-N

詳細

詳細

Chemical structure: pyridine

Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the α position.

生物化学的／生理学的作用

Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.

保管および安定性

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Non Combustible liquids.

その他情報

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable