P7136
ピラジンカルボキサミド
別名:
ピラジンアミド, ピラジン酸アミド
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| あなたへ/カタログ番号 | 在庫状況 | 単価 |
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この商品について
実験式（ヒル表記法）:
C5H5N3O
CAS番号:
分子量:
123.11
UNSPSC Code:
41116107
NACRES:
NA.85
PubChem Substance ID:
EC Number:
202-717-6
Beilstein/REAXYS Number:
112306
MDL number:
現在、価格および在庫状況を閲覧できません。
form
powder
Quality Segment
mp
189-191 °C (lit.)
antibiotic activity spectrum
mycobacteria
mode of action
cell membrane | interferes
SMILES string
NC(=O)c1cnccn1
InChI
1S/C5H5N3O/c6-5(9)4-3-7-1-2-8-4/h1-3H,(H2,6,9)
InChI key
IPEHBUMCGVEMRF-UHFFFAOYSA-N
Application
Pyrazinamide is used therapeutically as an antitubercular agent. Pyrazinamide is used to form polymeric copper complexes, create pyrazine carboxamide scaffolds useful as FXs inhibitors, and as a component of mycobacteria identification kits. It is used to study liver toxicity prevention [1] and mechanisms of resistance [2].
Biochem/physiol Actions
The active moiety of pyrazinamide is pyrazinoic acid (POA). POA is thought to disrupt membrane energetics and inhibit membrane transport function at acid pH in Mycobacterium tuberculosis. Iron enhances the antituberculous activity of pyrazinamide [3]. Pyrazinamide and its analogs have been shown to inhibit the activity of purified FAS I.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
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当該品目 | |||
|---|---|---|---|
| antibiotic activity spectrum mycobacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| mode of action cell membrane | interferes | mode of action - | mode of action - | mode of action - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form powder | form crystals | form powder | form - |
| mp 189-191 °C (lit.) | mp 118-120 °C (lit.) | mp 222-225 °C (dec.) (lit.) | mp 189-191 °C (lit.) |
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)