SAB4300040

Anti-phospho-CREB1 (pSer¹³³) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-CREB antibody produced in rabbit, Anti-MGC9284 antibody produced in rabbit, Anti-cAMP responsive element binding protein 1 antibody produced in rabbit
• MDL番号: MFCD01092316
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: ~43 kDa
• 交差性: mouse, human, rat
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (R-P-SP-Y-R)
• NCBIアクセッション番号: NP_004370.1
• UniProtアクセッション番号: P16220
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pSer133)
• 遺伝子情報: human ... CREB1(1385)

詳細

免疫原

Peptide sequence around phosphorylation site of serine 133 (R-P-S(p)-Y-R), according to the protein CREB1.

特徴および利点

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ターゲットの説明

CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories .

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable