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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
human
濃度
1 mg/mL
テクニック
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ACE2(59272)
詳細
Angiotensin-converting enzyme-2 (ACE2) gene is mapped to human chromosome Xp22.2. The gene codes for a membrane-associated and secreted enzyme. Ace 2 is a human homolog of angiotensin-converting enzyme (ACE) and is found mainly on endothelium. In humans, Ace2 is exclusively expressed in heart, kidney, and testis. The protein is characterized with an N-terminal PD and a C-terminal collectrin-like domain (CLD).
免疫原
Antibody was raised against a synthetic peptide corresponding to amino acids near the N terminus of human ACE2.
生物化学的／生理学的作用
Angiotensin-converting enzyme-2 (ACE2) aids in maturation of angiotensin (Ang) by converting Ang I to Ang1-9. It may also play a role in the local renin-angiotensin system (RAS) in heart and kidney. Ace 2 serves as a functional receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is responsible for causing coronavirus disease 2019 (COVID-19). Reduced expression of Ace 2 might cause cardiovascular diseases.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3500978.
物理的形状
1 mg/mLのPBS溶液（0.02％アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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関連製品
保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB3500978-100UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
この製品を見ている人はこちらもチェック
Jaśmina Bałaban et al.
Nanotechnology, science and applications, 16, 1-18 (2023-01-27)
The experiments aimed to document the presence of the ACE2 receptor on human muscle cells and the effects of the interaction of these cells with the spike protein of the SARS-CoV-2 virus in terms of induction of pro-inflammatory proteins, as
Emily J Sherman et al.
Scientific reports, 11(1), 15900-15900 (2021-08-07)
The membrane protein angiotensin-converting enzyme 2 (ACE2) is a physiologic regulator of the renin-angiotensin system and the cellular receptor for the SARS-CoV-2 virus. Prior studies of ACE2 expression have primarily focused on mRNA abundance, with investigation at the protein level
Bina Lee et al.
Cell reports. Medicine, 5(5), 101570-101570 (2024-05-16)
While an association between Parkinson's disease (PD) and viral infections has been recognized, the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on PD progression remains unclear. Here, we demonstrate that SARS-CoV-2 infection heightens the risk of PD using
M Donoghue et al.
Circulation research, 87(5), E1-E9 (2000-09-02)
ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was identified from 5' sequencing of a human heart failure ventricle cDNA library. ACE2 has an apparent signal peptide, a single metalloprotease active site, and a transmembrane domain. The metalloprotease
ACE2 is on the X chromosome: could this explain COVID-19 gender differences?
Esther Culebras et al.
European heart journal (2020-06-25)
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